The Effect of Intranasal Administration of Gangliosides on the Viability of CA1 Hippocampal Neurons in Rat Two-Vessel Occlusion Model of Forebrain Ischemia/Reperfusion Injury.

D K Avrova, L V Bayunova, N F Avrova, I O Zakharova

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Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

D K AvrovaLaboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

L V BayunovaLaboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

N F AvrovaLaboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.

I O ZakharovaLaboratory of Molecular Endocrinology and Neurochemistry, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia. zakhar@iephb.ru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intranasal administration of total bovine brain gangliosides (6 mg/kg) to rats protected the CA1 hippocampal neurons from the death caused by two-vessel occlusion model (with hypotension) of forebrain ischemia/reperfusion injury. The immunohistochemical reaction of specific antibodies to marker proteins of activated microglia (Iba1) and astrocytes (GFAP) in hippocampal slices revealed the neuroprotective effect of exogenous gangliosides which can be mostly explained by their ability to suppress neuroinflammation and gliosis. The expression of neurotrophic factor BDNF in the CA1 region of hippocampus did not differ in sham-operated rats and animals exposed to ischemia/reperfusion. However, the administration of gangliosides increased the BDNF expression in both control and ischemic groups. The intranasal route of administration allows using lower concentrations of gangliosides preventing the death of hippocampal neurons.

Indexed as

Administration, IntranasalBrain-Derived Neurotrophic FactorCA1 Region, HippocampalGangliosidesNeuronsNeuroprotective AgentsReperfusion InjuryAnimalsAstrocytesBrain IschemiaCalcium-Binding ProteinsCell SurvivalDisease Models, AnimalGlial Fibrillary Acidic ProteinMaleMicrofilament ProteinsAif1 protein, ratBdnf protein, ratBrain-Derived Neurotrophic FactorCalcium-Binding ProteinsGangliosidesGfap protein, ratGlial Fibrillary Acidic ProteinMicrofilament ProteinsNeuroprotective AgentsBDNFgangliosidesintranasal administrationischemianeuroinflammation

Identifiers

PMID38907060

DOI10.4103/1673-5374.250624

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