Evidence map›Paper›PMID 38907013›Full record

ArticleEuropean biophysics journal : EBJ2024

Computational discovery of dual potential inhibitors of SARS-CoV-2 spike/ACE2 and M

Boris D Bekono, Pascal Amoa Onguéné, Conrad V Simoben, Luc C O Owono, Fidele Ntie-Kang

Abstract read
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In one paragraph

Article in European biophysics journal : EBJ, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Boris D BekonoDepartment of Physics, Ecole Normale Supérieure, University of Yaoundé I, P. O. Box 47, Yaoundé, CM-00237, Cameroon. borisbekono@gmail.com.ORCID http://orcid.org/0000-0003-1077-4176
Pascal Amoa OnguénéCenter for Drug Discovery, Faculty of Science, University of Buea, P.O. Box 63, Buea, CM-00237, Cameroon.ORCID http://orcid.org/0000-0003-2919-6089
Conrad V SimobenCenter for Drug Discovery, Faculty of Science, University of Buea, P.O. Box 63, Buea, CM-00237, Cameroon.ORCID http://orcid.org/0000-0002-5958-6961
Luc C O OwonoDepartment of Physics, Ecole Normale Supérieure, University of Yaoundé I, P. O. Box 47, Yaoundé, CM-00237, Cameroon.
Fidele Ntie-KangCenter for Drug Discovery, Faculty of Science, University of Buea, P.O. Box 63, Buea, CM-00237, Cameroon. fidele.ntie-kang@ubuea.cm.ORCID http://orcid.org/0000-0003-0795-394X

Funding

Bill and Melinda Gates Foundation INV-055897Bill & Melinda Gates Foundation INV-036848LifeArc 10646
6 · The paper itself

Abstract

To find drugs against COVID-19, caused by the SARS-CoV-2, promising targets include the fusion of the viral spike with the human angiotensin-converting enzyme 2 (ACE2) as well as the main protease (M

Indexed as

Angiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus 3C ProteasesCOVID-19 Drug TreatmentDrug DiscoverySpike Glycoprotein, CoronavirusDrug Evaluation, PreclinicalHumansLigandsMolecular Docking SimulationMolecular Dynamics SimulationPharmacophoreProtein BindingQuantum TheorySARS-CoV-2ACE2 protein, humanAngiotensin-Converting Enzyme 2Antiviral AgentsCoronavirus 3C ProteasesLigandsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-23D-pharmacophoreACE2MproQuantum mechanicsSARS-CoV-2Virtual screening

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.