Evidence map›Paper›PMID 38907003›Full record

ArticleOncogene2024

Notch3-regulated microRNAs impair CXCR4-dependent maturation of thymocytes allowing maintenance and progression of T-ALL.

Ilaria Sergio, Claudia Varricchio, Sandesh Kumar Patel, Martina Del Gaizo, Eleonora Russo, Andrea Orlando, Giovanna Peruzzi, Francesca Ferrandino, Georgia Tsaouli, Sonia Coni and 13 more

Erratum issuedAbstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Notch Inhibitors and BH3 Mimetics in T-Cell Acute Lymphoblastic Leukemia.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

23 authors.

Ilaria Sergio *Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Claudia Varricchio *Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Sandesh Kumar Patel *Department of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Martina Del GaizoDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Eleonora RussoDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Andrea OrlandoDivision of Hematology & Medical Oncology, Department of Medicine, Weill Cornell Medicine, New York NY, USA.
Giovanna PeruzziCenter for Life Nano-Neuro Science, IIT, Rome, Italy.ORCID 0000-0002-6517-9107
Francesca FerrandinoA.O.R.N. dei colli Monaldi V., Napoli, Italy.
Georgia TsaouliDepartment of Medical-Surgical Science and Translational Medicine, Sapienza University of Rome, Rome, Italy.
Sonia ConiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Daniele PelusoPh.D School of Applied Medical-Surgical Sciences, Department of Biology, University of Rome "Tor Vergata", Rome, Italy.
Zein Mersini BesharatDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Federica CampoloDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Mary Anna VenneriDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Donatella Del BufaloPreclinical Models and New Therapeutic Agents Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.ORCID 0000-0002-3148-6096
Silvia LaiDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Stefano IndraccoloDepartment of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.ORCID 0000-0002-4810-7136
Sonia MinuzzoDepartment of Surgery Oncology and Gastroenterology, University of Padua, Padua, Italy.ORCID 0000-0003-2588-6058
Roberta La StarzaHematology Section, Department of Medicine and Surgery, and S. Maria Della Misericordia Hospital Perugia, CREO, Perugia, Italy.
Giovanni BernardiniDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0002-3705-2598
Isabella ScrepantiDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.ORCID 0000-0001-8071-9098
Antonio Francesco CampeseDepartment of Molecular Medicine, Sapienza University of Rome, Rome, Italy.
Maria Pia FelliDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy. mariapia.felli@uniroma1.it.ORCID 0000-0002-5765-2611

Funding

Ministero dell'Istruzione, dell'Università e della Ricerca (Ministry of Education, University and Research) ARS01_00432Sapienza Università di Roma (Sapienza University of Rome) AR1181643646B258Sapienza Università di Roma (Sapienza University of Rome) AR123188AF112A64Sapienza Università di Roma (Sapienza University of Rome) AR222181616D9D01Sapienza Università di Roma (Sapienza University of Rome) PH118164340087CFSapienza Università di Roma (Sapienza University of Rome) RM12117A71419448Sapienza Università di Roma (Sapienza University of Rome) RP12117A63FBA27CSapienza Università di Roma (Sapienza University of Rome) RP122181642E92CESapienza Università di Roma (Sapienza University of Rome) RP123188F3C01EB7
6 · The paper itself

Abstract

Malignant transformation of T-cell progenitors causes T-cell acute lymphoblastic leukemia (T-ALL), an aggressive childhood lymphoproliferative disorder. Activating mutations of Notch, Notch1 and Notch3, have been detected in T-ALL patients. In this study, we aimed to deeply characterize hyperactive Notch3-related pathways involved in T-cell dynamics within the thymus and bone marrow to propose these processes as an important step in facilitating the progression of T-ALL. We previously generated a transgenic T-ALL mouse model (N3-ICtg) demonstrating that aberrant Notch3 signaling affects early thymocyte maturation programs and leads to bone marrow infiltration by CD4

Indexed as

Disease ProgressionMicroRNAsPrecursor T-Cell Lymphoblastic Leukemia-LymphomaReceptor, Notch3Receptors, CXCR4ThymocytesAnimalsCell DifferentiationHumansMiceMice, TransgenicSignal TransductionCXCR4 protein, mouseMicroRNAsNotch3 protein, mouseReceptor, Notch3Receptors, CXCR4

Identifiers

PMID38907003

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.