Evidence map›Paper›PMID 38906991›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2024

Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.

Emma C Johnson, Isabelle Austin-Zimmerman, Hayley H A Thorpe, Daniel F Levey, David A A Baranger, Sarah M C Colbert, Ditte Demontis, Jibran Y Khokhar, Lea K Davis, Howard J Edenberg and 4 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Genetic and Proteomic Investigation of the Smoking-Parkinson's Disease Association.medRxiv : the preprint server for health sciences · 2026
    Article
  3. Article
  4. Review
  5. Cracking the chicken and egg problem of schizophrenia and substance use: Genetic interplay between schizophrenia, cannabis use disorder, and tobacco smoking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Emma C JohnsonDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA. emma.c.johnson@wustl.edu.ORCID http://orcid.org/0000-0003-0394-777X
Isabelle Austin-ZimmermanSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hayley H A ThorpeDepartment of Anatomy and Cell Biology, Western University, London, ON, Canada.
Daniel F LeveyDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
David A A BarangerDepartment of Psychological and Brain Sciences, Washington University in Saint Louis, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-6659-357X
Sarah M C ColbertDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-3060-7471
Ditte DemontisThe Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.ORCID http://orcid.org/0000-0001-9124-2766
Jibran Y KhokharDepartment of Anatomy and Cell Biology, Western University, London, ON, Canada.ORCID http://orcid.org/0000-0002-2169-2275
Lea K DavisDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5143-2282
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0003-0344-9690
Marta Di FortiSocial, Genetic, and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Sandra Sanchez-RoigeDepartment of Medicine, Division of Genetic Medicine, Vanderbilt University, Nashville, TN, USA.
Joel GelernterDivision of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-4067-1859
Arpana AgrawalDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-0313-793X

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genetic Basis of the Risk and Consequences of Cannabis Exposure in HumansR01DA058862 · NIDA · YALE UNIVERSITY · PI DEEPAK Cyril D'SOUZA, JOEL GELERNTER · 2023 to 2026
$2.6M
Building Bridges to Allow Cross-species Translational genetics for the Study of AddictionDP1DA054394 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANCHEZ ROIGE, SANDRA · 2021 to 2025
$2.4M
Identifying genetic sources of comorbidity between cannabis and schizophrenia using genome-wide and integrative omics dataK01DA051759 · NIDA · WASHINGTON UNIVERSITY · PI JOHNSON, EMMA COVEY · 2021 to 2025
$816k
Reciprocal longitudinal associations between brain function and alcohol use trajectories in adolescents and young adultsK99AA030808 · NIAAA · WASHINGTON UNIVERSITY · PI BARANGER, DAVID A · 2023 to 2024
$346k
Investigating the Genomic Architecture of Anxiety and Overlap with Mental Health Disorders in the Million Veteran Program.IK2BX005058 · VA · VA CONNECTICUT HEALTHCARE SYSTEM · PI LEVEY, DANIEL F · 2021 to 2025
–
BLRD VA IK2 BX005058Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) Canada Research Chair in Translational NeuropsychopharmacologyGouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) Postdoctoral FellowshipNCATS NIH HHS UL1 TR001863NIAAA NIH HHS K99 AA030808NIDA NIH HHS DP1 DA054394NIDA NIH HHS K01 DA051759NIDA NIH HHS R01 DA058862U.S. Department of Health & Human Services | NIH | National Institute on Alcohol Abuse and Alcoholism (NIAAA) K99AA030808U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) K01DA051759U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA058862U.S. Department of Veterans Affairs (Department of Veterans Affairs) 1IK2BX005058-01A2
6 · The paper itself

Abstract

Individuals with schizophrenia frequently experience co-occurring substance use, including tobacco smoking and heavy cannabis use, and substance use disorders. There is interest in understanding the extent to which these relationships are causal, and to what extent shared genetic factors play a role. We explored the relationships between schizophrenia (Scz; European ancestry N = 161,405; African ancestry N = 15,846), cannabis use disorder (CanUD; European ancestry N = 886,025; African ancestry N = 120,208), and ever-regular tobacco smoking (Smk; European ancestry N = 805,431; African ancestry N = 24,278) using the largest available genome-wide studies of these phenotypes in individuals of African and European ancestries. All three phenotypes were positively genetically correlated (r

Indexed as

Marijuana AbuseSchizophreniaTobacco SmokingBlack PeopleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansPolymorphism, Single NucleotideWhite People

Identifiers

PMID38906991
PMCPMC11399264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.