Evidence map›Paper›PMID 38906946›Full record

ArticleNPJ digital medicine2024

Validation and application of computer vision algorithms for video-based tremor analysis.

Maximilian U Friedrich, Anna-Julia Roenn, Chiara Palmisano, Jane Alty, Steffen Paschen, Guenther Deuschl, Chi Wang Ip, Jens Volkmann, Muthuraman Muthuraman, Robert Peach and 1 more

Abstract read
In one paragraph

Article in NPJ digital medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Unmet needs in functional neurological disorder related to digital healthcare.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026
    Review
  4. Probabilistic mapping of tremor control and gait ataxia risk in deep brain stimulation.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Video-Based Data-Driven Models for Diagnosing Movement Disorders: Review and Future Directions.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Combining video telemetry and wearable MEG for naturalistic imaging.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maximilian U Friedrich *Center for Brain Circuit Therapeutics, Brigham and Women's Hospital, Boston, MA, USA. mfriedrich1@bwh.harvard.edu.ORCID http://orcid.org/0000-0002-3695-1268
Anna-Julia Roenn *Department of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.
Chiara PalmisanoDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.
Jane AltyWicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, Tasmania, Australia.
Steffen PaschenDepartment of Neurology, University Kiel, Kiel, Germany.ORCID http://orcid.org/0000-0002-9306-8332
Guenther DeuschlDepartment of Neurology, University Kiel, Kiel, Germany.
Chi Wang IpDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.ORCID http://orcid.org/0000-0003-0484-385X
Jens VolkmannDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.
Muthuraman MuthuramanDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.ORCID http://orcid.org/0000-0001-6158-2663
Robert PeachDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany.
Martin M ReichDepartment of Neurology, University Hospital Wurzburg, Wuerzburg, Germany. reich_m1@ukw.de.ORCID http://orcid.org/0000-0001-9115-5136

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tremor is one of the most common neurological symptoms. Its clinical and neurobiological complexity necessitates novel approaches for granular phenotyping. Instrumented neurophysiological analyses have proven useful, but are highly resource-intensive and lack broad accessibility. In contrast, bedside scores are simple to administer, but lack the granularity to capture subtle but relevant tremor features. We utilise the open-source computer vision pose tracking algorithm Mediapipe to track hands in clinical video recordings and use the resulting time series to compute canonical tremor features. This approach is compared to marker-based 3D motion capture, wrist-worn accelerometry, clinical scoring and a second, specifically trained tremor-specific algorithm in two independent clinical cohorts. These cohorts consisted of 66 patients diagnosed with essential tremor, assessed in different task conditions and states of deep brain stimulation therapy. We find that Mediapipe-derived tremor metrics exhibit high convergent clinical validity to scores (Spearman's ρ = 0.55-0.86, p≤ .01) as well as an accuracy of up to 2.60 mm (95% CI [-3.13, 8.23]) and ≤0.21 Hz (95% CI [-0.05, 0.46]) for tremor amplitude and frequency measurements, matching gold-standard equipment. Mediapipe, but not the disease-specific algorithm, was capable of analysing videos involving complex configurational changes of the hands. Moreover, it enabled the extraction of tremor features with diagnostic and prognostic relevance, a dimension which conventional tremor scores were unable to provide. Collectively, this demonstrates that current computer vision algorithms can be transformed into an accurate and highly accessible tool for video-based tremor analysis, yielding comparable results to gold standard tremor recordings.

Identifiers

PMID38906946
PMCPMC11192937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.