Evidence map›Paper›PMID 38906922›Full record

ArticleScientific reports2024

Assessing the feasibility of test-and-cull and test-and-segregation approaches for the control of high-prevalence bovine tuberculosis in Ethiopian intensive dairy farms.

Matios Lakew, Biniam Tadesse, Sreenidhi Srinivasan, Muluken Aschalew, Bekele Andarge, Dirshaye Kebede, Addisu Etifu, Tena Alemu, Bekele Yalew, Teferi Benti and 11 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Matios LakewAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia. matioslakew@gmail.com.
Biniam TadesseAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Sreenidhi SrinivasanGlobal Health Initiative, Henry Ford Health, Detroit, MI, 48202, USA.
Muluken AschalewLivestock Development Institute, Bishoftu, Ethiopia.
Bekele AndargeLivestock Development Institute, Bishoftu, Ethiopia.
Dirshaye KebedeWolkite University, Gubre, Ethiopia.
Addisu EtifuWolkite University, Gubre, Ethiopia.
Tena AlemuWolkite University, Gubre, Ethiopia.
Bekele YalewAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Teferi BentiAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Abebe OlaniAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Shubisa AberaAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Wegene BedadaAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Abebe FromsaAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Getnet Abie MekonnenAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Gizat AlmawAnimal Health Institute, P.O. Box 04, Sebeta, Ethiopia.
Gobena AmeniAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Hagos AshenafiAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Balako GumiAklilu Lemma Institute of Pathobiology, Addis Ababa University, P.O. Box 1176, Addis Ababa, Ethiopia.
Douwe BakkerIndependent Researcher and Technical Consultant, Lelystad, The Netherlands. douwe.bakker@kpnmail.nl.
Vivek KapurDepartment of Animal Science, The Pennsylvania State University, University Park, PA, USA. vxk1@psu.edu.

Funding

Bill & Melinda Gates Foundation and the U.K. Department for International Development. OPP1176950
6 · The paper itself

Abstract

Bovine tuberculosis (bTB) is endemic and has a substantial impact on the livestock sector in Ethiopia and other low and middle-income countries (LMICs). With a national emphasis on dairy farm intensification to boost milk production and spur economic growth, the incidence of bTB is anticipated to rise. However, Ethiopia, like other LMICs, lacks a comprehensive national bTB control strategy due to the economic and social infeasibility of traditional test-and-cull (TC) approaches. To inform the development of such a strategy, we evaluated the effectiveness and feasibility of TC and test-and-segregation (TSg) strategies for bTB control on Ethiopian dairy farms. A TC approach was used at Farm A [N = 62; comparative cervical test (CCT) > 4 mm, starting prevalence 11.3%] while TSg was implemented at Farm B (N = 45; CCT > 4 mm, prevalence 22.2%), with testing intervals of 2-4 months. Both strategies achieved a reduction in bTB prevalence to 0%, requiring seven rounds of TC over 18 months at Farm A, and five rounds of TSg over 12 months at Farm B's negative herd. The results show that adopting more sensitive thresholds [CCT > 0 mm or single cervical test (SCT) > 2 mm] during later rounds was pivotal in identifying and managing previously undetected infections, emphasizing the critical need for optimized diagnostic thresholds. Cost analysis revealed that TC was approximately twice as expensive as TSg, primarily due to testing, labor, and cow losses in TC, versus construction of new facilities and additional labor for TSg. This underscores the economic and logistical challenges of bTB management in resource-limited settings. Taken together, our study highlights an urgent need for the exploration of alternative approaches including TSg and or vaccination to mitigate within herd transmission and enable implementation of bTB control in regions where TC is not feasible.

Indexed as

DairyingFeasibility StudiesTuberculosis, BovineAnimalsCattleEthiopiaFarmsFemaleMycobacterium bovisPrevalenceBovine tuberculosisDiagnostic thresholdsDisease controlEconomic implicationsTest-and-cullTest-and-segregation

Identifiers

PMID38906922
PMCPMC11192749

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.