Evidence map›Paper›PMID 38906910›Full record

ArticleScientific reports2024

Magneto-optical assessment of Plasmodium parasite growth via hemozoin crystal size.

Ágnes Orbán, Jan-Jonas Schumacher, Szilvia Mucza, Ana Strinic, Petra Molnár, Réka Babai, András Halbritter, Beáta G Vértessy, Stephan Karl, Stephan Krohns and 1 more

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ágnes OrbánDepartment of Physics, BME Budapest University of Technology and Economics, Budapest, 1111, Hungary. aorbanova@pasteur-kh.org.
Jan-Jonas SchumacherExperimental Physics 5, Center for Electronic Correlations and Magnetism, Institute of Physics, University of Augsburg, 86159, Augsburg, Germany.
Szilvia MuczaDepartment of Physics, BME Budapest University of Technology and Economics, Budapest, 1111, Hungary.
Ana StrinicExperimental Physics 5, Center for Electronic Correlations and Magnetism, Institute of Physics, University of Augsburg, 86159, Augsburg, Germany.
Petra MolnárMalaria Research Laboratory, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary.
Réka BabaiMalaria Research Laboratory, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary.
András HalbritterDepartment of Physics, BME Budapest University of Technology and Economics, Budapest, 1111, Hungary.
Beáta G VértessyMalaria Research Laboratory, Institute of Enzymology, Research Centre for Natural Sciences, Budapest, 1117, Hungary.
Stephan KarlVector-Borne Diseases Unit, PNG Institute of Medical Research, Madang, Madang Province, 511, Papua New Guinea.
Stephan KrohnsExperimental Physics 5, Center for Electronic Correlations and Magnetism, Institute of Physics, University of Augsburg, 86159, Augsburg, Germany.
István KézsmárkiExperimental Physics 5, Center for Electronic Correlations and Magnetism, Institute of Physics, University of Augsburg, 86159, Augsburg, Germany. istvan.kezsmarki@physik.uni-augsburg.de.

Funding

NHMRC Career Development Fellowship GNT1141441TKP2020 IES BME-IE-NAT
6 · The paper itself

Abstract

Hemozoin is a natural biomarker formed during the hemoglobin metabolism of Plasmodium parasites, the causative agents of malaria. The rotating-crystal magneto-optical detection (RMOD) has been developed for its rapid and sensitive detection both in cell cultures and patient samples. In the current article we demonstrate that, besides quantifying the overall concentration of hemozoin produced by the parasites, RMOD can also track the size distribution of the hemozoin crystals. We establish the relations between the magneto-optical signal, the mean parasite age and the median crystal size throughout one erythrocytic cycle of Plasmodium falciparum parasites, where the latter two are determined by optical and scanning electron microscopy, respectively. The significant correlation between the magneto-optical signal and the stage distribution of the parasites indicates that the RMOD method can be utilized for species-specific malaria diagnosis and for the quick assessment of drug efficacy.

Indexed as

HemeproteinsPlasmodium falciparumErythrocytesHumansMalaria, FalciparumMicroscopy, Electron, ScanningHemeproteinshemozoinHemozoinMagnetic nanoparticlesMagneto-optical detectionMalariaParticle size distribution

Identifiers

PMID38906910
PMCPMC11192761

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