ReviewAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2025
Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.
Review in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Understanding frailty across the kidney transplant continuum: a comprehensive systematic review of recent evidence.International urology and nephrology · 2026Pooled it
- Prevalence and risk factors of frailty among cardiac surgery patients: a systematic review and meta-analysis.Annals of medicine · 2025Pooled it
- Frailty risk prediction models in maintenance hemodialysis patients: a systematic review and meta-analysis of studies from China.Renal failure · 2025Pooled it
- Recommendations for the management of frailty in chronic kidney disease: a consensus report.Nature reviews. Nephrology · 2026Review
- Outcomes for Frail Dialysis Patients Not Referred for Transplantation: A Cohort Study.Journal of the American Geriatrics Society · 2026Article
- Factors Associated With Weight Management Referral Acceptance and Uptake in Kidney Transplant Candidates.Clinical transplantation · 2026Article
- Article
- Persistent metabolic acidosis and frailty trajectories after kidney transplantation: a prospective cohort study.Clinical and experimental nephrology · 2026Article
- Deciding between conservative kidney management and dialysis in older people with kidney failure: a narrative review.Clinical kidney journal · 2026Review
- Muscle Matters: Poor Muscle Quality Increases Mortality Risk in Early CKD.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Declining kidney function and frailty progression: a 7-year cohort study of Chinese middle-aged and older adults.The Journal of frailty & aging · 2026Article
- Characterizing the Clinical, Vascular, and Functional Phenotype of Metabolic Acidosis in Kidney Transplantation: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Changes in frailty and all-cause mortality in patients on hemodialysis: a prospective cohort study.BMC nephrology · 2026Article
- Integrated Ultrasound Approach to Fluid Assessment and Nutritional Status in Hemodialysis.Cardiorenal medicine · 2026Observational
- Frailty assessment in perioperative geriatric patients: a narrative review.Anesthesia and pain medicine · 2026Review
- Frailty Meets Cardio-oncology: A New Frontier in Personalised Cancer Care.European cardiology · 2026Review
- Evolution and interrelation of physical frailty and mild cognitive impairment up to two years after kidney transplantation: a multi-center prospective cohort study.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Falls, Frailty and Quality of Life Among Individuals on a Regular Haemodialysis Programme: Implications for Rehabilitation Nursing.International journal of environmental research and public health · 2025Observational
- Genetic and metabolomic pathways linking frailty, chronic kidney disease, and kidney failure: a Mendelian randomization and multi-omics analysis.Renal failure · 2025Article
- Supporting Shared Decision-Making in Life-Altering Kidney Therapy Decisions for Older Adults: A Review.JAMA internal medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Frailty is a multisystem syndrome of decreased physiologic reserve that has been shown to strongly and independently predict morbidity and mortality. Frailty is prevalent in patients living with kidney disease and occurs earlier in individuals with kidney disease as compared to the general population. In this comprehensive review, we examine clinical and research applications of frailty in kidney disease populations. Specifically, we clarify the definition of frailty and address common misconceptions, review the mechanisms and epidemiology of frailty in kidney disease, discuss challenges and limitations in frailty measurement, and provide updated evidence related to risk factors for frailty, its associated adverse outcomes, and interventions. We further add to the literature in this topic by highlighting the potential applications of frailty measurement in the care of patients with kidney disease and conclude with our recommendations for future research related to this important syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.