ArticleACS applied bio materials2024
3D-Printed Demineralized Bone Matrix-Based Conductive Scaffolds Combined with Electrical Stimulation for Bone Tissue Engineering Applications.
Article in ACS applied bio materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Granulate-to-Filament: An Extrusion-Mixed PLA-Human Bone Material System for 3D-Printed Bone Scaffolds.Journal of functional biomaterials · 2026Article
- Scaffold Design: A Review of Material and Immune Modulation in Bone Tissue Engineering.Cell and tissue banking · 2026Review
- Engineering Osteosarcoma In Vitro: From Traditional Models to Biofabricated Platforms for Precision Medicine.ACS omega · 2025Review
- Biomimetic Dual-Sensing Bone Scaffolds: Characterization and In Vitro Evaluation Under Dynamic Culturing Conditions.Biomimetics (Basel, Switzerland) · 2025Article
- 3D Printing of Conducting Polymer Hydrogels for Electrostimulation-Assisted Tissue Engineering.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Effects of electrical stimulation with alternating fields on the osseointegration of titanium implants in the rabbit tibia - a pilot study.Frontiers in bioengineering and biotechnology · 2024Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
Bone is remodeled through a dynamic process facilitated by biophysical cues that support cellular signaling. In healthy bone, signaling pathways are regulated by cells and the extracellular matrix and transmitted via electrical synapses. To this end, combining electrical stimulation (ES) with conductive scaffolding is a promising approach for repairing damaged bone tissue. Therefore, "smart" biomaterials that can provide multifunctionality and facilitate the transfer of electrical cues directly to cells have become increasingly more studied in bone tissue engineering. Herein, 3D-printed electrically conductive composite scaffolds consisting of demineralized bone matrix (DBM) and polycaprolactone (PCL), in combination with ES, for bone regeneration were evaluated for the first time. The conductive composite scaffolds were fabricated and characterized by evaluating mechanical, surface, and electrical properties. The DBM/PCL composites exhibited a higher compressive modulus (107.2 MPa) than that of pristine PCL (62.02 MPa), as well as improved surface properties (i.e., roughness). Scaffold electrical properties were also tuned, with sheet resistance values as low as 4.77 × 10
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