Evidence map›Paper›PMID 38905019›Full record

SynthesisJournal of pediatric psychology2025

Systematic review and meta-analysis of interventions to promote medication adherence among children, adolescents, and young adults with medical conditions.

Meghan E McGrady, Mary E Keenan-Pfeiffer, Amy C Lang, Amy E Noser, Anshul P Tyagi, Julia K Herriott, Rachelle R Ramsey

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Journal of pediatric psychology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meghan E McGradyDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.ORCID 0000-0002-3150-3239
Mary E Keenan-PfeifferDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Amy C LangDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Amy E NoserDepartment of Family Medicine and Community Health, University of Minnesota Medical School, Minneapolis, MN, United States.
Anshul P TyagiDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Julia K HerriottDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
Rachelle R RamseyDivision of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.

Funding

Enhancing treatment adherence and health outcomesT32HD068223 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Kevin Hommel, Meghan Eileen McGrady · 2012 to 2026
$3.6M
Using technology-assisted stepped-care interventions to improve adherence in adolescents with asthmaK23HL139992 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI RAMSEY, RACHELLE R. · 2019 to 2023
$868k
Eunice Kennedy ShriverEunice Kennedy Shriver National Institute of Child HealthHuman DevelopmentNHLBI NIH HHSNHLBI NIH HHS K23 HL139992NICHD NIH HHS T32 HD068223NIH HHSNIH HHS K23HL13992NIH HHS T32HD068223
6 · The paper itself

Abstract

objectiveThis meta-analysis examined the efficacy of adherence-promotion interventions for children, adolescents, and young adults prescribed a medication for > 90 days as part of a treatment regimen for a medical condition.

methodsA systematic literature review was conducted to identify randomized controlled trials of adherence-promotion interventions published between 2013 and 2023 and including children, adolescents, and/or young adults with a medical condition. A total of 38 articles representing 39 trials met inclusion criteria. A narrative synthesis was conducted to summarize included trials and a random-effects model was used to compute an overall intervention effect. Effect sizes by adherence outcome assessment methodology, participant age, and technology use were also computed.

resultsPediatric adherence-promotion interventions demonstrate a medium effect with those randomized to an intervention displaying greater improvements in medication adherence than those randomized to a comparator condition (SMD = 0.46, 95% CI: 0.31, 0.60, n = 37; 95% Prediction Interval: -0.32, 1.23).

conclusionsAdherence interventions for children, adolescents, and young adults with medical conditions increase adherence.

Indexed as

Health PromotionMedication AdherenceAdolescentChildHumansRandomized Controlled Trials as TopicYoung Adultadherence/self-managementmeta-analysispsychosocial interventionsystematic review

Identifiers

PMID38905019
PMCPMC12392408

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.