ArticleJournal of neuro-oncology2024
Neurosurgical resection of multiple brain metastases: outcomes, complications, and survival rates in a retrospective analysis.
Article in Journal of neuro-oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Supramarginal Resection of Metastatic Brain Tumors: A Meta-Analysis Study.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Risk stratification for unfavorable outcome after resection of selected brain metastases in patients with multiple brain metastases.Journal of neuro-oncology · 2026Article
- Which Clinical, Radiological, Inflammatory, and Lesion-Related Characteristics Are Associated with Early Neurological Decompensation After Intracranial Mass Lesion Surgery?Diagnostics (Basel, Switzerland) · 2026Article
- Sarcopenic obesity and cachexia as nutritional risk phenotypes and histology-specific outcomes after intracranial tumor resection: a histology-stratified NSQIP analysis of 27,057 cases.Neurosurgical review · 2026Article
- Breast cancer brain metastasis: from molecular insights to therapeutic innovation.Frontiers in immunology · 2026Review
- Clinical outcomes and survival benefits of craniotomy in breast cancer patients with brain metastases: Focusing on candidate selection and early mortality.Brain & spine · 2026Article
- Surgical resection with postoperative stereotactic radiosurgery versus stereotactic radiosurgery alone for large (>3 cm) multiple brain metastases: a propensity score-matched analysis.Frontiers in oncology · 2026Article
- Article
- Postoperative hydrocephalus in patients with infratentorial brain metastases may be influenced by preoperative treatment: a single-center cohort study.Journal of neuro-oncology · 2025Article
- Evaluating the Impact of Index Metastasis Resection in Patients with Multiple Brain Metastases.Cancers · 2025Article
- Surgical resection for multiple brain metastases: a systematic review and meta-analysis of functional and survival outcomes.Medicine and pharmacy reports · 2025Review
- Surgical treatment of multiple breast cancer brain metastases: clinical characteristics and factors impacting postoperative survival.Journal of neuro-oncology · 2025Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigates the outcomes of microsurgical resection of multiple brain metastasis (BMs).
methodsThis retrospective, monocentric analysis included clinical data from all consecutive BM patients, who underwent simultaneous resection of ≥ 2 BMs between January 2018 and May 2023. Postoperative neurological and functional outcomes, along with perioperative complications, as well as survival data were evaluated.
resultsA total of 47 patients, with a median age of 61 years (IQR 48-69), underwent 73 craniotomies (median 2; range 1-3) for resection of 104 BMs. Among patients, 80.8% presented with symptomatic BMs, causing focal neurological deficits in 53% of cases. Gross total resection was achieved in 87.2% of BMs. Karnofsky Performance Scale (KPS) scores improved in 42.6% of patients, remained unchanged in 46.8%, and worsened in 10.6% after surgery. Perioperative complications were observed in 29.8% of cases, with transient complications occurring in 19.2% and permanent deficits in 10.6%. The 30-days mortality rate was 2.1%. Logistic regression identified eloquent localization (p = 0.036) and infratentorial craniotomy (p = 0.018) as significant predictors of postoperative complications. Concerning overall prognosis, patients with permanent neurological deficits post-surgery (HR 11.34, p = 0.007) or progressive extracranial disease (HR: 4.649; p = 0.006) exhibited inferior survival.
conclusionMicrosurgical resection of multiple BMs leads to clinical stabilization or functional improvement in most patients. Although transient complications do not affect overall survival, the presence of persistent neurological deficits (> 3 months post-surgery) and progressive extracranial disease negatively impact overall survival. This highlights the importance of careful patient selection for resection of multiple BMs.
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