Evidence map›Paper›PMID 38904836›Full record

ArticleMikrochimica acta2024

Tetrahedral DNA-linked aptamer-antibody-based sandwich-type electrochemical sensor with Ag@Au core-shell nanoparticles as a signal amplifier for highly sensitive detection of α-fetoprotein.

Xiaoying Pei, Junhong Liu, Yulong Zhang, Yan Huang, Zhongfang Li, Xueliang Niu, Weili Zhang, Wei Sun

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoying PeiSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China.
Junhong LiuSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China.
Yulong ZhangSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China.
Yan HuangSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China.
Zhongfang LiSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China.
Xueliang NiuSchool of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo, 255049, P. R. China. xueliangniu@sdut.edu.cn.ORCID http://orcid.org/0000-0001-7986-698X
Weili ZhangCollege of Pharmacy, Key Laboratory of Biomedical Engineering and Technology in Universities of Shandong, Qilu Medical University, Zibo, 255300, P. R. China. 23774989@qq.com.
Wei SunHainan Engineering Research Center of Tropical Ocean Advanced Optoelectronic Functional Materials, Hainan International Joint Research Center of Marine Advanced Photoelectric Functional Materials, Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, Key Laboratory of Functional Materials and Photoelectrochemistry of Haikou, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, 571158, P. R. China. swyy26@hotmail.com.

Funding

National Natural Science Foundation of China 21964007National Natural Science Foundation of China 22172093the Open Foundation of Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, China 2023LTOM06the Shandong Provincial Natural Science Foundation ZR2021MB103
6 · The paper itself

Abstract

The conventional electrochemical detection strategy for alpha-fetoprotein (AFP) is limited by the antigen-antibody (Ag-Ab) reactions and suffers from low sensitivity and poor reproducibility due to the inconsistency of Ab-modified electrodes. Herein, we designed and explored a sandwich-type electrochemical sensor for highly sensitive detection of AFP based on aptamer (Apt)-AFP-Ab interaction mode with silver@gold (Ag@Au) core-shell nanoparticles (NPs) as a signal amplifier. AuNPs were electrodeposited onto MXene (Ti

Indexed as

alpha-FetoproteinsAptamers, NucleotideBiosensing TechniquesElectrochemical TechniquesGoldLimit of DetectionMetal NanoparticlesSilverDNAElectrodesHumansHydrogen Peroxidealpha-FetoproteinsAptamers, NucleotideDNAGoldHydrogen PeroxideSilverAg@AuNPsAptamer-antibody modeModified glassy carbon electrodeMXeneSandwich-type sensorTetrahedral DNAα-fetoprotein

Identifiers

PMID38904836

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.