Evidence map›Paper›PMID 38904834›Full record

ArticleInternational ophthalmology2024

Double implantation of Xen 45 gel stent in primary open-angle glaucoma: a pilot study.

Andrea Grosso, Piero Ceruti, Jacopo Garlasco, Jacqueline Fröhlich, Matteo Orione, Konstantin Gugleta, Mauro Fioretto, Giacomo Calzetti

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Article in International ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea GrossoOphthalmology Unit, ASL Alessandria "Santo Spirito" Hospital, Casale Monferrato, Italy. 78andreagrosso@gmail.com.
Piero CerutiEye Clinic, Department of Neurological and Visual Sciences, University of Verona, Verona, Italy.
Jacopo GarlascoDepartment of Public Health and Paediatrics, University of Turin, Turin, Italy.
Jacqueline FröhlichDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Matteo OrioneOphthalmology Unit, ASL Alessandria "Santo Spirito" Hospital, Casale Monferrato, Italy.
Konstantin GugletaDepartment of Ophthalmology, University of Basel, Basel, Switzerland.
Mauro FiorettoOphthalmology Unit, ASL Alessandria "Santo Spirito" Hospital, Casale Monferrato, Italy.
Giacomo CalzettiDepartment of Ophthalmology, University of Basel, Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo describe the outcomes of double implantation of Xen 45 Gel Stent (Xen) using an ab externo approach with closed conjunctiva.

methodsRetrospective single-centre case series of primary open-angle glaucoma patients with at least six months of follow-up after implantation of a second Xen in the same eye via ab externo technique without conjunctival opening.

resultsEight pseudophakic eyes of 8 patients were included. Intraocular pressure (IOP) dropped from 30 ± 2.6 mmHg pre-operatively to 22.4 ± 2.3 mmHg one month after the first Xen implant (mean difference: -7.6 mmHg [95% confidence interval: -9.4, -5.9 mmHg], p = 0.0092). A second Xen was then implanted to achieve the target IOP. The procedure showed no significant intraoperative or postoperative complications. The IOP dropped to 16.1 ± 2.7 mmHg six months following this second implant (mean difference: -6.3 mmHg [95% confidence interval: -7.2, -5.3 mmHg], p = 0.0183); however, 3 patients needed medical therapy to further reduce the IOP towards the target value.

conclusionSequential implantation of two Xen 45 Gel Stents using an ab externo approach with closed conjunctiva appears a promising procedure that showed a favorable safety and efficacy profile in this small case series. This pilot data might pave the way for further studies to evaluate the safety and efficacy of the procedure.

Indexed as

Glaucoma Drainage ImplantsGlaucoma, Open-AngleIntraocular PressureProsthesis DesignStentsAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPilot ProjectsProsthesis ImplantationRetrospective StudiesTreatment OutcomeAb externoDouble XenMinimally invasive glaucoma surgeryPrimary open-angle glaucomaXen 45 gel stent

Identifiers

PMID38904834

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.