Evidence map›Paper›PMID 38904737›Full record

Trial reportCell and tissue banking2024

Effect of cell therapy with adipose-derived stem cells in the treatment of acute rupture of the Achilles tendon in humans.

Maria Helena Costa Vieira, Laynna de Carvalho Schweich-Adami, Rodrigo Juliano Oliveira, Andréia Conceição Milan Brochado Antoniolli-Silva

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Cell and tissue banking, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maria Helena Costa VieiraSetor de Ortopedia e Traumatologia, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso do Sul - UFMS, Campo Grande, MS, Brasil.ORCID http://orcid.org/0009-0009-5314-8723
Laynna de Carvalho Schweich-AdamiCentro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso Do Sul - UFMS, Campo Grande, MS, Brasil.ORCID http://orcid.org/0000-0002-9838-7340
Rodrigo Juliano OliveiraCentro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso Do Sul - UFMS, Campo Grande, MS, Brasil.ORCID http://orcid.org/0000-0003-3514-3346
Andréia Conceição Milan Brochado Antoniolli-SilvaCentro de Estudos em Células Tronco, Terapia Celular e Genética Toxicológica - CeTroGen, Hospital Universitário Maria Aparecida Pedrossian - HUMAP, Universidade Federal de Mato Grosso Do Sul - UFMS, Campo Grande, MS, Brasil. andreia@corporesanosaude.com.br.ORCID http://orcid.org/0000-0002-2525-7019

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico Chamada: PQ - 2021 / Número do Processo: 316246/2021-2 / Termo de Outorga: 1089700081951461Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul , Brasil UNIVERSAL - MS N° 10/2015; Nº SIAFIC: 25846
6 · The paper itself

Abstract

The aim of this study was to evaluate the effect of adipose-derived stem cells (ADSCs) in the treatment of acute rupture of the Achilles tendon. It was a cross-sectional study involving 15 patients. Patients were randomly divided: group 1-rupture; group 2-suture; group 3-rupture + ADSCs. In the AOFAS score, the score was higher in group 3 with a significant difference. In the ATRS score, the score was higher in groups 2 and 3, also with a significant difference. As for the ultrasound score, there was a significant difference between the experimental groups in relation to this score, however, in the multiple comparisons test, comparing two groups at a time, it was possible to observe a significant difference of the experimental groups. It can be concluded that cell therapy in this condition may be a treatment option due to tissue regeneration and significant recovery of function.

Indexed as

Achilles TendonAdipose TissueAdultCell- and Tissue-Based TherapyCross-Sectional StudiesFemaleHumansMaleMiddle AgedRuptureStem CellsStem Cell TransplantationTendon InjuriesTreatment OutcomeAchilles tendonADSCs, orthopedicsCell therapyRegenerative medicine

Identifiers

PMID38904737

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.