ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2024
Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 · What the graph read from it
What it found
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2 · The registry
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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5 · Who and what money
Authors and funding
18 authors.
Catherine MetayerDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California.ORCID 0000-0003-3467-4145
Logan G SpectorDivision of Epidemiology and Clinical Research, Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota.ORCID 0000-0003-2516-0222
Michael E ScheurerDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0002-8379-6088
Soyoung JeonCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California.ORCID 0000-0002-2916-6595
Rodney J ScottFaculty of Medicine and Health, School of Biomedical Science and Pharmacy, Hunter Medical Research Institute, University of Newcastle, New Lambton, Australia.ORCID 0000-0001-7724-3404
Masatoshi TakagiDepartment of Pediatrics and Developmental Biology, Tokyo Medical and Dental University, Tokyo, Japan.ORCID 0000-0002-7580-9184
Jacqueline ClavelInserm UMR1153, Epidemiology of Childhood and Adolescent Cancers (EPICEA) Team, Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and Statistics (CRESS), Paris, France.ORCID 0000-0002-3616-7676
Atsushi ManabeDepartment of Pediatrics, Hokkaido University, Sapporo, Japan.ORCID 0000-0002-6698-2348
Xiaomei MaDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.ORCID 0000-0001-9472-8032
Elleni M HailuDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California.ORCID 0000-0002-0879-6176
Philip J LupoDivision of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas.ORCID 0000-0003-0978-5863
Kevin Y UrayamaDepartment of Social Medicine, National Center for Child Health and Development, Tokyo, Japan.ORCID 0000-0002-1360-9531
Audrey BonaventureInserm UMR1153, Epidemiology of Childhood and Adolescent Cancers (EPICEA) Team, Université Paris Cité and Université Sorbonne Paris Nord, Inserm, INRAE, Center for Research in Epidemiology and Statistics (CRESS), Paris, France.ORCID 0000-0001-6665-8145
Motohiro KatoDepartment of Pediatrics, The University of Tokyo, Tokyo, Japan.ORCID 0000-0001-5145-1774
Aline MeirhaegheUniversité de Lille, INSERM, Centre Hospitalier Universitaire de Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de Risque et Déterminants Moléculaires des Maladies Liées au Vieillissement, Lille, France.ORCID 0000-0001-6983-2364
Charleston W K ChiangCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California.ORCID 0000-0002-0668-7865
Libby M MorimotoDivision of Epidemiology, School of Public Health, University of California, Berkeley, Berkeley, California.ORCID 0000-0002-1509-739X
Joseph L WiemelsCenter for Genetic Epidemiology, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California.ORCID 0000-0003-4838-9951
Funding
Training CoreP42ES004705 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI SMITH, MARTYN T · 1987 to 2025
$74.6M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
Environmental and Molecular Epidemiology of Childhood LeukemiaR01ES009137 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 1999 to 2013
$21.1M
Genome-Wide Association Study of Childhood Leukemia by Hispanic StatusR01CA155461 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MA, XIAOMEI, WIEMELS, JOSEPH LEO · 2011 to 2014
$4.1M
Support For Infrastructure of Childhood Leukemia Environmental ResearchR24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Catherine Metayer · 2017 to 2026
$2.3M
An evolutionary framework to elucidate and interpret the genetic architecture of complex traits in diverse populations - diversity supplementR35GM142783 · NIGMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHIANG, CHARLESTON · 2021 to 2025
$2.2M
Lifespan Psychosocial Profiles and Biological Pathways to Bone StrengthR01AG033067 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CRANDALL, CAROLYN JANET, KARLAMANGLA, ARUN S · 2009 to 2012
$1.4M
Support For Infrastructure of Childhood Leukemia Environmental ResearchU24ES028524 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI METAYER, CATHERINE · 2023 to 2025
backgroundPrenatal folate supplementation has been consistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity and led to inconclusive results.
methodsWe evaluated whether ∼2,900 single-nucleotide polymorphisms (SNP) within 46 candidate genes involved in the folate metabolism pathway influence the risk of childhood ALL, using genome-wide data from nine case-control studies in the Childhood Cancer and Leukemia International Consortium (n = 9,058 cases including 4,510 children of European ancestry, 3,018 Latinx, and 1,406 Asians, and 92,364 controls). Each study followed a standardized protocol for quality control and imputation of genome-wide data and summary statistics were meta-analyzed for all children combined and by major ancestry group using METAL software.
resultsNone of the selected SNPs reached statistical significance, overall and for major ancestry groups (using adjusted Bonferroni P-value of 5 × 10-6 and less-stringent P-value of 3.5 × 10-5 accounting for the number of "independent" SNPs). None of the 10 top (nonsignificant) SNPs and corresponding genes overlapped across ancestry groups.
conclusionsThis large meta-analysis of original data does not reveal associations between many common genetic variants in the folate metabolism pathway and childhood ALL in various ancestry groups. IMPACT: Genetic variants in the folate pathway alone do not appear to substantially influence childhood acute lymphoblastic leukemia risk. Other mechanisms such as gene-folate interaction, DNA methylation, or maternal genetic effects may explain the observed associations with self-reported prenatal folate intake.
Indexed as
Folic AcidPolymorphism, Single NucleotidePrecursor Cell Lymphoblastic Leukemia-LymphomaCase-Control StudiesChildChild, PreschoolFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleRisk FactorsFolic Acid
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Folate Metabolism and Risk of Childhood Acute Lymphoblastic Leukemia: A Genetic Pathway Analysis from the Childhood Cancer and Leukemia International Consortium. · full record | OpenQuestion