Evidence map›Paper›PMID 38904247›Full record

ArticleJournal of the American Heart Association2024

ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells.

Yu-An Lu, Jiacheng Sun, Lu Wang, Meimei Wang, Yalin Wu, Anteneh Getachew, Rachel C Matthews, Hui Li, William Gao Peng, Jianyi Zhang and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Complex-specific HDAC1/2 regulation in the heart: insights from MiDAC disruption.American journal of physiology. Heart and circulatory physiology · 2026
    Article
  4. Loss of Elmsan1 in cardiomyocytes leads to age-dependent cardiac dysfunction and reduced lifespan.American journal of physiology. Heart and circulatory physiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yu-An LuDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-2516-4031
Jiacheng SunDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-2306-0124
Lu WangDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-3550-4757
Meimei WangDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.
Yalin WuDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0009-0003-8772-6671
Anteneh GetachewDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0001-6154-9214
Rachel C MatthewsDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.
Hui LiDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.
William Gao PengDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.
Jianyi ZhangDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-3955-6554
Rui LuDepartment of Medicine, Division of Hematology/Oncology, Heersink School of Medicine University of Alabama at Birmingham Birmingham AL.ORCID 0000-0003-1593-2612
Yang ZhouDepartment of Biomedical Engineering, Heersink School of Medicine, School of Engineering University of Alabama at Birmingham Birmingham AL.ORCID 0000-0002-9217-5208

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hesham Sadek · 2022 to 2026
$13.1M
Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large AnimalsR01HL149137 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SADEK, HESHAM, ZANGI, LIOR · 2019 to 2022
$2.5M
Molecular Regulation of Functional Maturation in Human Direct Cardiac ReprogrammingR01HL153220 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Yang Zhou · 2020 to 2026
$2.0M
MEF2D-Mediated Transcriptional Control of Acute Myeloid LeukemiaR01CA259480 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Rui Lu · 2022 to 2026
$1.7M
American Heart Association-American Stroke Association 969529NCI NIH HHS R01 CA259480NHLBI NIH HHS P01 HL160476NHLBI NIH HHS R01 HL149137NHLBI NIH HHS R01 HL153220
6 · The paper itself

Abstract

backgroundELMSAN1 (ELM2-SANT domain-containing scaffolding protein 1) is a newly identified scaffolding protein of the MiDAC (mitotic deacetylase complex), playing a pivotal role in early embryonic development. Studies on METHODS AND

resultsWe generated

conclusionsIn this study, we address the significance of the direct involvement of ELMSAN1 in the differentiation and maturation of hiPSC cardiomyocytes. We first report the impact of ELMSAN1 on multiple aspects of hiPSC cardiomyocyte generation, including cardiac differentiation, sarcomere formation, calcium handling, electrophysiological maturation, and proliferation.

Indexed as

Cell DifferentiationInduced Pluripotent Stem CellsMyocytes, CardiacAcetylationCalcium SignalingCells, CulturedCo-Repressor ProteinsHistonesHumansSarcomeresCo-Repressor ProteinsHistonesMIDEAS protein, humanacetylationcardiomyocyteELMSAN1hiPSCmaturationMiDAC

Identifiers

PMID38904247
PMCPMC11255699

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.