Evidence map›Paper›PMID 38904157›Full record

ArticleACS synthetic biology2024

Directed Evolution of a Bacterial Leucyl tRNA in Mammalian Cells for Enhanced Noncanonical Amino Acid Mutagenesis.

Rachel L Huang, Delilah Jewel, Rachel E Kelemen, Quan Pham, Tarah J Yared, Shu Wang, Soumya Jyoti Singha Roy, Zeyi Huang, Samantha D Levinson, Bharathi Sundaresh and 3 more

Abstract read
In one paragraph

Article in ACS synthetic biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. An Expanded Toolbox for Versatile Chemical Editing of Adeno-Associated Virus.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Tuning tRNAs for improved translation.Frontiers in genetics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rachel L HuangDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Delilah JewelDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Rachel E KelemenDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Quan PhamDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Tarah J YaredDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Shu WangDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Soumya Jyoti Singha RoyDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID 0000-0002-7999-4591
Zeyi HuangDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Samantha D LevinsonDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Bharathi SundareshBiology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Suyen Espinoza MirandaBiology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Tim van OpijnenBiology Department, Boston College, Chestnut Hill, Massachusetts 02467, United States.
Abhishek ChatterjeeDepartment of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, United States.ORCID 0000-0002-6231-5302

Funding

Predicting the emergence of antibiotic resistance through multi-omics approaches and Immune System-surveillanU01AI124302 · NIAID · BOSTON COLLEGE · PI BENTO, JOSE, COOPER, VAUGHN · 2016 to 2020
$10.2M
A genetically encoded toolset to decipher the biology of post-translational modifications in the mammalian proteomeR35GM136437 · NIGMS · BOSTON COLLEGE · PI Abhishek Chatterjee · 2020 to 2026
$4.0M
NIAID NIH HHS U01 AI124302NIGMS NIH HHS R35 GM136437
6 · The paper itself

Abstract

The

Indexed as

Amino AcidsDirected Molecular EvolutionEscherichia coliMutagenesisHEK293 CellsHumansLeucine-tRNA LigaseAmino AcidsLeucine-tRNA Ligaseadeno-associated virusdirected evolution in mammalian cellsE. coli leucyl-tRNAgenetic code expansionnonsense suppression

Identifiers

PMID38904157
PMCPMC11789822

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.