Evidence map›Paper›PMID 38904134›Full record

Observational studyBMJ open2024

Performance of

Monica Molano, Dorothy A Machalek, Grace Tan, Suzanne Garland, Prisha Balgovind, Gholamreza Haqshenas, Gloria Munnull, Samuel Phillips, Steven G Badman, John Bolnga and 10 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Organoid technology in cervical cancer research.American journal of cancer research · 2025
    Review
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Monica MolanoCentre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia monica.molanoluque@thewomens.org.au.ORCID 0000-0002-9167-1234
Dorothy A MachalekCentre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia.
Grace TanAustralian Centre for the Prevention of Cervical Cancer, Melbourne, Victoria, Australia.
Suzanne GarlandThe Royal Women's Hospital, Parkville, Victoria, Australia.
Prisha BalgovindMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Gholamreza HaqshenasThe Royal Women's Hospital, Parkville, Victoria, Australia.
Gloria MunnullPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Samuel PhillipsMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Steven G BadmanKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
John BolngaPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.ORCID 0000-0003-1214-9817
Alyssa Marie CornallMurdoch Children's Research Institute, Parkville, Victoria, Australia.
Josephine GabuzziPapua New Guinea Institute of Medical Research, Goroka, Papua New Guinea.
Zure KombatiTininga Clinic, Mount Hagen General Hospital, Mount Hagen, Western Highlands Province, Papua New Guinea.
Julia BrothertonAustralian Centre for the Prevention of Cervical Cancer, Melbourne, Victoria, Australia.
Marion SavilleAustralian Centre for the Prevention of Cervical Cancer, Melbourne, Victoria, Australia.
David HawkesAustralian Centre for the Prevention of Cervical Cancer, Melbourne, Victoria, Australia.
John KaldorKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.
Pamela Josephine TolimanKirby Institute -Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Andrew John VallelyKirby Institute, University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-1558-4822
Gerald L MurrayCentre for Women's Infectious Diseases, The Royal Women's Hospital, Parkville, Victoria, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWHO recommends human papillomavirus (HPV) testing for cervical screening, with triage of high-risk HPV (hrHPV) positive women. However, there are limitations to effective triage for low-resource, high-burden settings, such as Papua New Guinea. In this exploratory study, we assessed the performance of host methylation as triage tools for predicting high-grade squamous intraepithelial lesions (HSIL) in self-collected and clinician-collected samples.

designExploratory observational study.

settingProvincial hospital, same-day cervical screen-and-treat trial, Papua New Guinea.

participants44 hrHPV+women, with paired self/clinician-collected samples (4 squamous cell carcinomas (SCC), 19 HSIL, 4 low-grade squamous intraepithelial lesions, 17 normal). PRIMARY AND SECONDARY OUTCOME MEASURES: Methylation levels of

resultsIn clinician-collected samples,

conclusion

Indexed as

Cell Adhesion Molecule-1DNA MethylationEarly Detection of CancerMicroRNAsMyelin and Lymphocyte-Associated Proteolipid ProteinsPapillomavirus InfectionsTriageUterine Cervical NeoplasmsAdultBiomarkers, TumorCarcinoma, Squamous CellFemaleHumansMiddle AgedPapua New GuineaSensitivity and SpecificityBiomarkers, TumorCADM1 protein, humanCell Adhesion Molecule-1MAL protein, humanMicroRNAsMIRN124 microRNA, humanMyelin and Lymphocyte-Associated Proteolipid Proteinshuman papillomavirus virusesmolecular biologymolecular diagnosticsoncogenes

Identifiers

PMID38904134
PMCPMC11191780

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.