Evidence map›Paper›PMID 38904096›Full record

ArticleGut microbes

Modulation of Alzheimer's disease brain pathology in mice by gut bacterial depletion: the role of IL-17a.

Wenlin Hao, Qinghua Luo, Inge Tomic, Wenqiang Quan, Tobias Hartmann, Michael D Menger, Klaus Fassbender, Yang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Immune dysfunction in Alzheimer disease.Nature reviews. Neuroscience · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenlin HaoDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Qinghua LuoDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Inge TomicDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Wenqiang QuanDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Tobias HartmannGerman Institute for Dementia Prevention (DIDP), Saarland University, Homburg/Saar, Germany.
Michael D MengerDepartment of Experimental Surgery, Saarland University, Homburg/Saar, Germany.
Klaus FassbenderDepartment of Neurology, Saarland University, Homburg/Saar, Germany.
Yang LiuDepartment of Neurology, Saarland University, Homburg/Saar, Germany.ORCID 0000-0002-7614-4233

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal models; however, the underlying mechanism remains unclear. In this study, 3-month-old APP-transgenic female mice with and without knock-out of

Indexed as

Alzheimer DiseaseBrainGastrointestinal MicrobiomeInterleukin-17Amyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAnti-Bacterial AgentsBlood-Brain BarrierCD4-Positive T-LymphocytesDisease Models, AnimalFemaleHumansLow Density Lipoprotein Receptor-Related Protein-1MiceMice, Inbred C57BLAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnti-Bacterial AgentsIl17a protein, mouseInterleukin-17Low Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseAlzheimer’s diseaseamyloid pathologyand Il-17agut microbiomemicroglia

Identifiers

PMID38904096
PMCPMC11195493

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.