Evidence map›Paper›PMID 38904075›Full record

ArticleGut and liver2025

Impact of Donor Age on Liver Transplant Outcomes in Patients with Acute-on-Chronic Liver Failure: A Cohort Study.

Jie Zhou, Danni Ye, Shenli Ren, Jiawei Ding, Tao Zhang, Siyao Zhang, Zheng Chen, Fangshen Xu, Yu Zhang, Huilin Zheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut and liver, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jie ZhouDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0001-9150-1713
Danni YeDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0000-0002-5929-0263
Shenli RenDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0009-0001-1753-3220
Jiawei DingDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0009-0003-0684-6648
Tao ZhangDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0009-0004-3878-9307
Siyao ZhangDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0000-0002-1071-3755
Zheng ChenDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0000-0002-4072-7541
Fangshen XuDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu, China.ORCID 0009-0003-3323-4321
Yu ZhangDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0009-0005-5164-6447
Huilin ZhengSchool of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, China.ORCID 0000-0003-3845-6612
Zhenhua HuDivision of Hepatobiliary and Pancreatic Surgery, Department of Surgery, First Affiliated Hospital, Zhejiang University, School of Medicine, Hangzhou, China.ORCID 0000-0002-8636-0757

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Liver transplantation is the most effective treatment for the sickest patients with acute-on-chronic liver failure (ACLF). However, the influence of donor age on liver transplantation, especially in ACLF patients, is still unclear. Methods: In this study, we used the data of the Scientific Registry of Transplant Recipients. We included patients with ACLF who received liver transplantation from January 1, 2007, to December 31, 2017, and the total number was 13,857. We allocated the ACLF recipients by age into group I (donor age ≤17 years, n=647); group II (donor age 18-59 years, n=11,423); and group III (donor age ≥60 years, n=1,787). Overall survival (OS), graft survival, and mortality were compared among the three age groups and the four ACLF grades. Cox regression was also analyzed. Results: The 1-, 3-, and 5-year OS rates were 89.6%, 85.5%, and 82.0% in group I; 89.4%, 83.4%, and 78.2% in group II; and 86.8%, 78.4%, and 71.4% in group III, respectively (p<0.001). When we analyzed the different effects of donor age on OS with different ACLF grades, in groups II and III, we observed statistical differences. Finally, the cubic spline curve told us that the relative death rate changed linearly with increasing donor age. Conclusions: Donor age is related to OS and graft survival of ACLF patients after transplantation, and poorer results were associated with elderly donors. In addition, different donor ages have different effects on recipients with different ACLF grades.

Indexed as

Acute-On-Chronic Liver FailureLiver TransplantationTissue DonorsAdolescentAdultAgedAge FactorsCohort StudiesFemaleGraft SurvivalHumansMaleMiddle AgedRegistriesRetrospective StudiesTreatment OutcomeAcute-on-chronic liver failureAgeGraft survivalLiver transplantationOverall survival

Identifiers

PMID38904075
PMCPMC12070216

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.