Evidence map›Paper›PMID 38904066›Full record

ArticleiScience2024

Novel requirements for HAP2/GCS1-mediated gamete fusion in

Jennifer F Pinello, Josef Loidl, Ethan S Seltzer, Donna Cassidy-Hanley, Daniel Kolbin, Anhar Abdelatif, Félix A Rey, Rocky An, Nicole J Newberger, Yelena Bisharyan and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. A distinct subclade of AlkB family demethylases in ciliates safeguards the positional fidelity of eukaryotic NProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Jennifer F PinelloDepartment of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA.
Josef LoidlDepartment of Chromosome Biology, Max Perutz Labs, University of Vienna, Vienna, Austria.
Ethan S SeltzerDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Donna Cassidy-HanleyDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Daniel KolbinDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Anhar AbdelatifDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Félix A ReyUnité de Virologie Structurale, Institut Pasteur, 75724 Paris, France.
Rocky AnDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Nicole J NewbergerDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Yelena BisharyanOffice of Technology Development, Harvard University, Cambridge, MA 02138, USA.
Hayk PapoyanDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Haewon ByunDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Hector C AguilarDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
Alex L LaiDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Jack H FreedDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14850, USA.
Timothy MaugelDepartment of Biology, Laboratory for Biological Ultrastructure, University of Maryland, College Park, MD 20742, USA.
Eric S ColeBiology Department, St. Olaf College, Northfield, MN 55057, USA.
Theodore G ClarkDepartment of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.

Funding

A Resource Center for Tetrahymena ThermophilaP40OD010964 · OD · WASHINGTON UNIVERSITY · PI DOUGLAS LEE CHALKER · 2012 to 2026
$6.5M
National Biomedical Resource for Electron-Spin Resonance Spectroscopy (ACERT)R24GM146107 · NIGMS · CORNELL UNIVERSITY · PI BRIAN R CRANE, Jack H Freed · 2022 to 2026
$6.4M
Advancing our knowledge of viral membrane fusion and of IDP-membrane interactions by ESRR35GM148272 · NIGMS · CORNELL UNIVERSITY · PI Jack H Freed · 2023 to 2026
$1.9M
Membrane proteins driving a cell-cell fusion reaction during fertilizationK99GM146112 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI PINELLO, JENNIFER FRICKE · 2022 to 2023
$225k
NIGMS NIH HHS K99 GM146112NIGMS NIH HHS R24 GM146107NIGMS NIH HHS R35 GM148272NIH HHS P40 OD010964
6 · The paper itself

Abstract

The ancestral gamete fusion protein, HAP2/GCS1, plays an essential role in fertilization in a broad range of taxa. To identify factors that may regulate HAP2/GCS1 activity, we screened mutants of the ciliate

Indexed as

Cell biologyMolecular biology

Identifiers

PMID38904066
PMCPMC11187246

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.