Evidence map›Paper›PMID 38904027›Full record

ReviewInternational journal of biological sciences2024

Polyphenols as Therapeutics in Respiratory Diseases: Moving from Preclinical Evidence to Potential Clinical Applications.

Talha Bin Emran, Taslima Akter Eva, Mehrukh Zehravi, Fahadul Islam, Jishan Khan, Shaik Kareemulla, Uppuluri Varuna Naga Venkata Arjun, Anitha Balakrishnan, Poonam Popatrao Taru, Firzan Nainu and 6 more

Abstract readReview
In one paragraph

Review in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Talha Bin EmranDepartment of Pathology and Laboratory Medicine, Warren Alpert Medical School, Brown University, Providence, RI 02912, USA.
Taslima Akter EvaDepartment of Pharmacy, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh.
Mehrukh ZehraviDepartment of Clinical Pharmacy, College of Dentistry & Pharmacy, Buraydah Private Colleges, Buraydah 51418, Saudi Arabia.
Fahadul IslamDepartment of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Jishan KhanDepartment of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.
Shaik KareemullaDepartment of Pharmacy Practice, M. M. College of Pharmacy (Maharishi Markandeshwar Deemed University), Mullana-Ambala, Haryana 133207, India.
Uppuluri Varuna Naga Venkata ArjunDepartment of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science, Technology, and Advanced Studies (VISTAS), Tamil Nadu, India.
Anitha BalakrishnanDepartment of Pharmaceutics, GRT Institute of Pharmaceutical Education and Research, Tiruttani, India.
Poonam Popatrao TaruDepartment of Pharmacognosy, School of Pharmacy, Vishwakarma University, Kondhwa, Pune, India.
Firzan NainuDepartment of Pharmacy, Faculty of Pharmacy, Hasanuddin University, Makassar 90245, Indonesia.
Emil SalimDepartment of Pharmacology and Clinical/Community Pharmacy, Faculty of Pharmacy, Universitas Sumatera Utara, Medan, 20155, Indonesia.
Safia Obaidur RabDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia.
Mohamed H NafadyFaculty of Applied Health Science Technology, Misr University for Science and Technology, Giza 12568, Egypt.
Polrat WilairatanaDepartment of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.
Moon Nyeo ParkDepartment of Pathology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02453, Republic of Korea.
Bonglee KimDepartment of Pathology, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02453, Republic of Korea.

Funding

NIEHS NIH HHS 27302C0038
6 · The paper itself

Abstract

Respiratory diseases are the most common and severe health complication and a leading cause of death worldwide. Despite breakthroughs in diagnosis and treatment, few safe and effective therapeutics have been reported. Phytochemicals are gaining popularity due to their beneficial effects and low toxicity. Polyphenols are secondary metabolites with high molecular weights found at high levels in natural food sources such as fruits, vegetables, grains, and citrus seeds. Over recent decades, polyphenols and their beneficial effects on human health have been the subject of intense research, with notable successes in preventing major chronic non-communicable diseases. Many respiratory syndromes can be treated effectively with polyphenolic supplements, including acute lung damage, pulmonary fibrosis, asthma, pulmonary hypertension, and lung cancer. This review summarizes the role of polyphenols in respiratory conditions with sufficient experimental data, highlights polyphenols with beneficial effects for each, and identifies those with therapeutic potential and their underlying mechanisms. Moreover, clinical studies and future research opportunities in this area are discussed.

Indexed as

PolyphenolsAnimalsHumansRespiratory Tract DiseasesPolyphenolsARDSAsthmaLung cancerPolyphenolsRespiratory diseasesTuberculosis

Identifiers

PMID38904027
PMCPMC11186353

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.