ArticleFrontiers in cardiovascular medicine2024
Lung transplantation following controlled hypothermic storage with a portable lung preservation device: first multicenter European experience.
Article in Frontiers in cardiovascular medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Optimizing Lung Transplant Logistics Using Controlled Hypothermic Preservation to Extend Ischemic Time.Transplantation direct · 2026Article
- Concomitant bilateral lung transplantation and diaphragmatic hernia repair: A case report.JTCVS techniques · 2026Article
- Article
- What is the current state of clinical evidence for static lung preservation devices, and is it sufficient to inform clinical practice?Clinics (Sao Paulo, Brazil) · 2026Article
- Validation of the thermal stability of EMAIS-SR autonomous packaging for preservation of porcine lungs: cooling curve in an experimental model.Sao Paulo medical journal = Revista paulista de medicina · 2026Article
- Institut Georges Lopez-2M as a Novel Lung Preservation Solution Attenuates Ischemia-Reperfusion Injury in a RatTransplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Revisiting optimal static lung preservation techniques in an era when machine perfusion is transforming organ recovery: thermoregulation is still an important concept.Journal of thoracic disease · 2025Review
- Temperature Dynamics of Porcine and Human Lungs During Static Ice Storage: Ice Is Not 4 °C.Journal of clinical medicine · 2025Article
- Pushing the Survival Bar Higher: Two Decades of Innovation in Lung Transplantation.Journal of clinical medicine · 2024Review
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32 authors.
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Abstract
Introduction: Compared with traditional static ice storage, controlled hypothermic storage (CHS) at 4-10°C may attenuate cold-induced lung injury between procurement and implantation. In this study, we describe the first European lung transplant (LTx) experience with a portable CHS device. Methods: A prospective observational study was conducted of all consecutively performed LTx following CHS (11 November 2022 and 31 January 2024) at two European high-volume centers. The LUNGguard device was used for CHS. The preservation details, total ischemic time, and early postoperative outcomes are described. The data are presented as median (range: minimum-maximum) values. Results: A total of 36 patients underwent LTx (i.e., 33 bilateral, 2 single LTx, and 1 lobar). The median age was 61 (15-68) years; 58% of the patients were male; 28% of the transplantations had high-urgency status; and 22% were indicated as donation after circulatory death. In 47% of the patients, extracorporeal membrane oxygenation (ECMO) was used for perioperative support. The indications for using the CHS device were overnight bridging ( Conclusion: CHS seems safe and feasible despite the high-risk recipient and donor profiles, as well as extended preservation times. PGD3 at 72 h was observed in 2.8% of the patients. This technology could postpone LTx to daytime working hours. Larger cohorts and longer-term outcomes are required to confirm these observations.
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