Evidence map›Paper›PMID 38903945›Full record

ArticleRSC medicinal chemistry2024

Cytotoxicity of phosphoramidate, bis-amidate and cycloSal prodrug metabolites against tumour and normal cells.

Rebecca E Farrell, Harrison Steele, Ryan J Middleton, Danielle Skropeta, Guo-Jun Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RSC medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca E FarrellSchool of Chemistry & Molecular Bioscience and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong Wollongong NSW 2522 Australia skropeta@uow.edu.au.ORCID https://orcid.org/0000-0002-1934-970X
Harrison SteeleSchool of Chemistry & Molecular Bioscience and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong Wollongong NSW 2522 Australia skropeta@uow.edu.au.ORCID https://orcid.org/0009-0001-9139-3705
Ryan J MiddletonAustralian Nuclear Science and Technology Organisation Lucas Heights NSW 2234 Australia gdl@ansto.gov.au.ORCID https://orcid.org/0000-0001-8024-7772
Danielle SkropetaSchool of Chemistry & Molecular Bioscience and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong Wollongong NSW 2522 Australia skropeta@uow.edu.au.ORCID https://orcid.org/0000-0002-2293-7916
Guo-Jun LiuAustralian Nuclear Science and Technology Organisation Lucas Heights NSW 2234 Australia gdl@ansto.gov.au.ORCID https://orcid.org/0000-0002-4278-8372

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phosphonate and phosphate prodrugs are integral to enhancing drug permeability, but the potential toxicity of their metabolites requires careful consideration. This study evaluates the impact of widely used phosphoramidate, bis-amidate, and cycloSal phosph(on)ate prodrug metabolites on BxPC3 pancreatic cancer cells, GL261-Luc glioblastoma cells, and primary cultured mouse astrocytes. 1-Naphthol and 2-naphthol demonstrated the greatest toxicity. Notably, 2-naphthol exhibited an ED

Identifiers

PMID38903945
PMCPMC11109934

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.