Evidence map›Paper›PMID 38903854›Full record

ArticleJournal of circulating biomarkers

Relation between interleukin-13 and annexin-V levels and carotid intima-media thickness in nephrotic syndrome.

Asmaa A Elsehmawy, Rasha M Gouda, Fatma Elzhraa A E Diab, Ola I Saleh, Heba M Galal, Mona G Al Anany, Salwa S Abd Elgawad, Marwa M Hassan, Mohamed A M Kamal, Ahmed Y Elamir

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In one paragraph

Article in Journal of circulating biomarkers. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Asmaa A ElsehmawyPediatric Department, Al-Azhar University, Cairo - Egypt.
Rasha M GoudaPediatric Department, Al-Azhar University, Cairo - Egypt.
Fatma Elzhraa A E DiabClinical Pathology Department, Al-Azhar University, Cairo - Egypt.
Ola I SalehRadiology Department, Al-Azhar University, Cairo - Egypt.
Heba M GalalRadiology Department, Al-Azhar University, Cairo - Egypt.
Mona G Al AnanyPhysiology Department, Al-Azhar University, Cairo - Egypt.
Salwa S Abd ElgawadPediatric Department, Al-Azhar University, Cairo - Egypt.
Marwa M HassanCommunity Medicine Department, Al-Azhar University, Cairo - Egypt.
Mohamed A M KamalClinical Pathology Department, Al-Azhar University, Cairo - Egypt.
Ahmed Y ElamirRadiology Department, Cairo University, Cairo - Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: The aim of the current study is to assess the relation between carotid intima-media thickness (CIMT) measurements, renal Doppler resistive index (RI) and serum levels of interleukin-13 (IL-13) and annexin-V (An-V) in children with idiopathic nephrotic syndrome (INS). Materials and methods: The present case-control study was conducted on 60 children with INS and 60 age- and sex-matched healthy children. All participants were subjected to evaluation of serum levels of IL-13 and An-V and ultrasound Doppler measurement of CIMT and renal RI. Results: Patients expressed significantly higher An-V (5.9 ± 2.6 vs. 2.1 ± 0.8 ng/mL, p<0.001) and IL-13 (19.2 ± 7.6 vs. 3.4 ± 1.4 ng/L) levels when compared with healthy counterparts. Moreover, it was shown that patients had significantly higher CIMT (0.49 ± 0.06 vs. 0.35 ± 0.03, p<0.001) as compared to controls. No significant differences were noted between the studied groups regarding right or left RIs. Correlation analysis identified significant direct correlation between serum An-V levels and albumin/creatinine ratio (ACR) (r = 0.55), cholesterol (r = 0.48), triglycerides (r = 0.36), IL-13 (r = 0.92) and CIMT (r = 0.53). Similar correlations could be found between serum IL-13 levels and CIMT measurements and the corresponding parameters. Conclusions: The present study suggests an association between higher early atherosclerosis expressed as elevated CIMT measurements in children with INS and elevated serum levels of An-V and IL-13.

Indexed as

Annexin-VCarotid intima-media thicknessIdiopathic nephrotic syndromeInterleukin-13

Identifiers

PMID38903854
PMCPMC11188736

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.