ArticleFrontiers in medicine2024
Relationship between Life's Essential 8 and metabolic syndrome among older Americans (NHANES, 2007-2010): navigating biological aging and inflammation.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Gender differences in the association between Life's essential 8 and cardiovascular disease: a U.S.-based cross-sectional analysis.Nutrition & metabolism · 2025Article
- Biological aging traits mediate the association between cardiovascular health levels and all-cause and cardiovascular mortality among adults in the U.S. without cardiovascular disease.Biogerontology · 2025Article
- The mediating and joint effects of depression in the association between cardiovascular health and frailty in middle-aged and elderly people: evidence from NHANES.Frontiers in psychiatry · 2025Article
- Curvilinear relationship between life's crucial 9 and metabolic syndrome in U.S. adults: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Exploring the impact of women-specific reproductive factors on phenotypic aging and the role of life's essential 8.Nutrition journal · 2024Article
- Socio Ecological Model (SEM) and Diffusion of Innovation (DOI) Integrated Framework: A Proposal for Integration to Improve Intervention in the Digital Age of Medicine.Innovations in pharmacy · 2024Article
- Article
- Impact of serum carotenoids on cardiovascular mortality risk in middle-aged and elderly adults with metabolic syndrome.Frontiers in nutrition · 2024Article
- Association between life's essential 8 and hyperuricemia among adults in the United States: insights from NHANES 2005-2018.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
8 authors.
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Abstract
Background: Metabolic syndrome (MetS) is a global health concern, and it is particularly harmful to middle-aged and elderly individuals. Life Element Eight (LE8), a measure to improve cardiovascular health, may offer benefits for MetS. Herein, we examined the relationship between LE8 and MetS among middle-aged and elderly individuals, and elucidated the role of biological aging and inflammation in this process. Methods: We obtained the LE8 scores of 2,901 Americans, along with their biological aging indicators (Biological age, Phenotypic age, Serum Klotho), and computed their inflammatory indicators SII, DII. Using logistic regression model, we assessed the association among inflammatory markers, Biological aging, LE8 and MetS. Additionally, we generated restricted cubic spline (RCS) plots to display trends in significant variables in logistic regression. Using parallel mediation analysis, we evaluated the possible mediating role of various factors in the risk relationship between LE8 and MetS. Results: Our examination revealed that higher LE8 scores were associated with a lower incidence of MetS in a fully adjusted model. The high LE8 subgroup had a 79.73% reduction in the risk of MetS compared to the low subgroup with an OR = 0.2027 (95% Cl 0.0871, 0.4714), with similar correlations between health factor scores and MetS risk. Biological aging mediated the associations between LE8, health behaviors and health factor scores and MetS risk. Conclusion: A rise in the LE8 score among middle-aged and elderly individuals is a protective factor for MetS, and this association may be partially mediated by biological aging, suggesting that LE8 may reduce the risk of MetS by ameliorating aging.
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