ArticleFrontiers in veterinary science2024
Perineural invasion as a predictor of local recurrence in cats with squamous cell carcinoma treated with electrochemotherapy.
Article in Frontiers in veterinary science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Rare Feline Gingival Extramedullary Plasmacytoma: Clinical Application of Electrochemotherapy for Local Control.Veterinary medicine and science · 2026Article
- Electrical resistance measurement in feline cutaneous squamous cell carcinoma treated with electrochemotherapy: a pilot study.Scientific reports · 2026Article
- Recurrence Rates for Mandibular Fibrosarcoma Associated With Mandibular Canal Invasion Following Mandibulectomy Procedures in Dogs.Veterinary and comparative oncology · 2026Article
- Invasive Squamous Cell Carcinoma of the Larynx in a Dog.Case reports in veterinary medicine · 2026Article
- Aggressive basal cell carcinoma in a non-facial location in a cat: Perineural and lymphatic invasion with metastasis.Open veterinary journal · 2025Article
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6 authors.
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Abstract
Introduction: Squamous cell carcinoma (SCC) is a malignant neoplasm that accounts for approximately 15-25% and 70-80% of all feline cutaneous and oral tumors, respectively. Similar to that in humans, feline SCC can be highly invasive locally; however, its metastasis rate is low. Thus, effective local treatment may be curative for most patients, and includes surgery, electrochemotherapy (ECT), cryosurgery, or a combination of these. However, this neoplasia can manifest more aggressively in some patients, leading to higher recurrence rates. In humans, perineural invasion (PNI) has been described as a relevant tumor dissemination pathway associated with high-risk SCC, resulting in higher recurrence rates, resistance to local treatments, and short survival. However, PNI and its prognostic value have not been described in feline SCC. This study aimed to evaluate the PNI in a feline population with SCC treated with ECT and correlate its presence with the occurrence of local recurrence and other clinical variables. Methods: Twenty-four cats histopathologically diagnosed with SCC between 2013 and 2021 were retrospectively selected from the medical records of the Oncological Center Vet Cancer (São Paulo, SP, Brazil). The inclusion criteria were ECT as the sole therapy, histopathological evaluation of PNI, and absence of distant metastatic disease. Results: The complete response rate was 96% (23/24), and PNI was identified in 33% of the cats (8/24, PNI-positive group), whereas 67% were free of this invasion (16/24, PNI-negative group). All PNI-positive cats developed local recurrence, whereas only five PNI-negative cats experienced recurrence. Local recurrence was significantly associated with PNI ( Discussion: The results of this study are preliminary but promising. The data obtained are the first regarding PNI occurrence in feline SCC and pave the way for further studies, mainly to correlate the PNI with survival data and better define its prognostic value.
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