Evidence map›Paper›PMID 38903561›Full record

ArticleRegenerative biomaterials2024

Promoting cell proliferation and collagen production with ascorbic acid 2-phosphate-releasing poly(l-lactide-co-ε-caprolactone) membranes for treating pelvic organ prolapse.

Alma Kurki, Kaarlo Paakinaho, Markus Hannula, Sanna Karjalainen, Kirsi Kuismanen, Jari Hyttinen, Susanna Miettinen, Reetta Sartoneva

Abstract read
In one paragraph

Article in Regenerative biomaterials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alma KurkiBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.ORCID https://orcid.org/0000-0001-7978-6293
Kaarlo PaakinahoBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.
Markus HannulaBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.
Sanna KarjalainenBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.
Kirsi KuismanenDepartment of Obstetrics and Gynaecology, Tampere University Hospital, 33520 Tampere, Finland.
Jari HyttinenBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.
Susanna MiettinenBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.
Reetta SartonevaBiomedical Technology (TECH) Research Unit, Faculty of Medicine and Health Technology (MET), Tampere University, 33520 Tampere, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic organ prolapse (POP) afflicts millions of women globally. In POP, the weakened support of the pelvic floor results in the descent of pelvic organs into the vagina, causing a feeling of bulging, problems in urination, defaecation and/or sexual function. However, the existing surgical repair methods for relapsed POP remain insufficient, highlighting the urgent need for more effective alternatives. Collagen is an essential component in pelvic floor tissues, providing structural support, and its production is controlled by ascorbic acid. Therefore, we investigated novel ascorbic acid 2-phosphate (A2P)-releasing poly(l-lactide-co-ε-caprolactone) (PLCL

Indexed as

adipose-derived stem/stromal cellascorbic acid 2-phosphatepelvic organ prolapsepoly(l-lactide-co-ε-caprolactone)tissue engineering

Identifiers

PMID38903561
PMCPMC11187500

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.