Evidence map›Paper›PMID 38903513›Full record

ArticleFrontiers in immunology2024

André J Esgalhado, Débora Reste-Ferreira, Sandra Weinhold, Markus Uhrberg, Elsa M Cardoso, Fernando A Arosa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

André J EsgalhadoHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, Portugal.
Débora Reste-FerreiraHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, Portugal.
Sandra WeinholdInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Markus UhrbergInstitute for Transplantation Diagnostics and Cell Therapeutics, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University, Düsseldorf, Germany.
Elsa M CardosoHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, Portugal.
Fernando A ArosaHealth Sciences Research Centre, University of Beira Interior (CICS-UBI), Covilhã, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-driven human effector-memory CD8+ T cells expressing low levels of the CD8β chain have been previously described. However, little is known on a possible antigen-independent trigger. We have examined the impact that IL-15 has on the expression of CD8β on purified human naïve CD8+ T cells after CFSE labeling and culture with IL-15. As expected, IL-15 induced naïve CD8+ T cells to proliferate and differentiate. Remarkably, the process was associated with a cell-cycle dependent down-modulation of CD8β from the cell surface, leading to the generation of CD8αβ

Indexed as

CD8 AntigensCD8-Positive T-LymphocytesInterleukin-15Lymphocyte ActivationCell DifferentiationCell ProliferationCells, CulturedDown-RegulationHumansCD8 AntigensCD8beta antigenIL15 protein, humanInterleukin-15CD8α chainCD8β chaindownregulationeffector-memory CD8+ T cellsIL-15naïve CD8+ T cells

Identifiers

PMID38903513
PMCPMC11188365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.