Evidence map›Paper›PMID 38903508›Full record

ArticleFrontiers in immunology2024

Human milk oligosaccharides regulate human macrophage polarization and activation in response to

Stine Dam Jepsen, Astrid Lund, Martin Matwiejuk, Lars Andresen, Kristine Rothaus Christensen, Søren Skov

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stine Dam Jepsendsm-firmenich, Hørsholm, Denmark.
Astrid LundImmunology, Section for Preclinical Disease Biology, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Martin Matwiejukdsm-firmenich, Hørsholm, Denmark.
Lars AndresenImmunology, Section for Preclinical Disease Biology, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.
Kristine Rothaus Christensendsm-firmenich, Hørsholm, Denmark.
Søren SkovImmunology, Section for Preclinical Disease Biology, Department of Veterinary and Animal Sciences, University of Copenhagen, Frederiksberg, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human milk oligosaccharides (HMOs) are present in high numbers in milk of lactating women. They are beneficial to gut health and the habitant microbiota, but less is known about their effect on cells from the immune system. In this study, we investigated the direct effect of three structurally different HMOs on human derived macrophages before challenge with

Indexed as

CytokinesMacrophage ActivationMacrophagesMilk, HumanOligosaccharidesPhagocytosisStaphylococcus aureusCell DifferentiationCells, CulturedFemaleHumansStaphylococcal InfectionsCytokinesOligosaccharides2′-fucosyllactose6′-sialyllactosehuman milk oligosaccharidesimmunologylacto-N-neotetraosemyeloid activationStaphylococcus aureus

Identifiers

PMID38903508
PMCPMC11187579

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.