Evidence map›Paper›PMID 38903502›Full record

ReviewFrontiers in immunology2024

Dendritic cell subsets and implications for cancer immunotherapy.

Michael Y Chen, Felicia Zhang, Simon Peter Goedegebuure, William E Gillanders

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. B cells in cancer: functions, mechanisms and therapeutic advances.Signal transduction and targeted therapy · 2026
    Review
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  5. Enterovirus infections in children.Pediatric investigation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Michael Y Chen *Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
Felicia Zhang *Department of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
Simon Peter GoedegebuureDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, United States.
William E GillandersDepartment of Surgery, Washington University School of Medicine, St. Louis, MO, United States.

Funding

SURGICAL ONCOLOGY TRAINING GRANTT32CA009621 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN, William E. Gillanders · 1988 to 2026
$12.9M
Washington University SPORE in Pancreatic CancerP50CA272213 · NCI · WASHINGTON UNIVERSITY · PI David G DeNardo, WILLIAM G HAWKINS · 2023 to 2026
$10.7M
Targeting Neoantigens in Triple Negative Breast CancerR01CA240983 · NCI · WASHINGTON UNIVERSITY · PI GILLANDERS, WILLIAM E., SCHREIBER, ROBERT DAVID · 2019 to 2023
$3.2M
NCI NIH HHS P50 CA272213NCI NIH HHS R01 CA240983NCI NIH HHS T32 CA009621
6 · The paper itself

Abstract

Dendritic cells (DCs) play a central role in the orchestration of effective T cell responses against tumors. However, their functional behavior is context-dependent. DC type, transcriptional program, location, intratumoral factors, and inflammatory milieu all impact DCs with regard to promoting or inhibiting tumor immunity. The following review introduces important facets of DC function, and how subset and phenotype can affect the interplay of DCs with other factors in the tumor microenvironment. It will also discuss how current cancer treatment relies on DC function, and survey the myriad ways with which immune therapy can more directly harness DCs to enact antitumor cytotoxicity.

Indexed as

Dendritic CellsImmunotherapyNeoplasmsTumor MicroenvironmentAnimalsHumansantigen presentationcancer immune therapycancer vaccinationdendritic cell (DC)dendritic cell subtypesdendritic cell targetingdendritic cell vaccinetumor neoantigen

Identifiers

PMID38903502
PMCPMC11188312

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.