ArticleIndian journal of anaesthesia2024
Dexmedetomidine for reducing succinylcholine-induced myalgia in patients undergoing electroconvulsive therapy: A randomised controlled trial.
Article in Indian journal of anaesthesia, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Electroconvulsive therapy research in India: A scoping review.Indian journal of psychiatry · 2026Review
- Indian Journal of Anaesthesia Infographics of published articles.Indian journal of anaesthesia · 2025Article
- Enhancing clinical decision-making: The imperative of reporting number needed to treat in anaesthesia research.Indian journal of anaesthesia · 2025Article
- Hypothesis reporting in randomised controlled trials: A critical appraisal of IJA 2024 publications.Indian journal of anaesthesia · 2025Article
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4 authors.
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Abstract
Background and Aim: Electroconvulsive therapy (ECT) is an effective intervention for psychiatric patients. Succinylcholine is considered the drug of choice for muscle relaxation for ECT. Significant adverse effects of succinylcholine include fasciculation and myalgia. Dexmedetomidine is a highly selective α-2 adrenergic agonist. This study aims to determine the efficacy of a low dose of dexmedetomidine in reducing succinylcholine-induced myalgia in patients receiving ECT. Methods: This randomised controlled trial was conducted on 100 patients, aged 18-65 years, undergoing ECT, who were randomly allocated into two groups with an allocation ratio of 1:1. Group D received intravenous (IV) dexmedetomidine 0.25 µg/kg, and Group C received IV normal saline (0.9%). Patients' self-reported myalgia scores were measured after 60 min of the procedure. Fasciculations were noted after IV succinylcholine administration. Heart rate (HR) and mean blood pressure (MBP) were measured at baseline, after infusion (5 min) and after ECT (0, 2.5, 5, 10, 15, 30 min). Continuous data were analysed using a Student's Results: There were no differences between the groups regarding demographics. Myalgia and fasciculations were less in Group D than in Group C ( Conclusion: A low dose of dexmedetomidine (0.25 µg/kg) effectively reduces myalgia and fasciculations due to succinylcholine in patients undergoing electroconvulsive therapy.
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