Evidence map›Paper›PMID 38903247›Full record

ArticleDiscovery immunology2024

IL-21 conditions antigen-presenting human γδ T-cells to promote IL-10 expression in naïve and memory CD4

Christopher J Tyler, Inva Hoti, Daniel D Griffiths, Simone M Cuff, Robert Andrews, Maximilian Keisker, Raya Ahmed, Hinrich P Hansen, James O Lindsay, Andrew J Stagg and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Discovery immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christopher J TylerDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Inva HotiCentre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Daniel D GriffithsDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0009-0001-5312-511X
Simone M CuffDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Robert AndrewsSystems Immunity Research Institute, Cardiff University, Cardiff, UK.
Maximilian KeiskerDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Raya AhmedDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Hinrich P HansenDepartment of Internal Medicine I, University of Cologne, Cologne, Germany.
James O LindsayCentre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Andrew J StaggCentre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Bernhard MoserDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.
Neil E McCarthyCentre for Immunobiology, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Matthias EberlDivision of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, UK.ORCID https://orcid.org/0000-0002-9390-5348

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Direct interaction between T-cells exerts a major influence on tissue immunity and inflammation across multiple body sites including the human gut, which is highly enriched in 'unconventional' lymphocytes such as γδ T-cells. We previously reported that microbial activation of human Vγ9/Vδ2

Indexed as

antigen presentationCD4+ T-cellsmucosal immunityRNAsequnconventional T-cells

Identifiers

PMID38903247
PMCPMC11187773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.