ReviewChemical science2024
The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions.
Review in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Scalable Synthesis of a Masked Thiophenol as an Air-Stable, Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680).Organic process research & development · 2026Article
- Sustainable Mizoroki-Heck Cross-Coupling Using a Pd(II)-Polymer as Precatalyst in 1‑Butanol.ACS omega · 2026Article
- Reassessment of Recycling Rates of Platinum Group Metals (PGMs) and Their Impact on Sustainability Models.ACS omega · 2026Review
- Porous Phenazine-bridged Tetraoxa[8]Circulenes for Selective Gold Recovery and Heterogeneous Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Iron Catalyzed Aryl-Aryl Kumada Cross-Coupling: A Mechanistic and Computational Investigation.Angewandte Chemie (International ed. in English) · 2026Article
- Electronic and Steric Effects of the ProPhos Ligand Family for Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaromatics.ACS catalysis · 2026Article
- Recent Advances in Homogeneous Catalysis with Platinum Group Pincer Complexes: Hydrogen-Mediated Transformations and Cross-Coupling Reactions.Chemical record (New York, N.Y.) · 2026Review
- Process-Ready Nickel-Catalyzed Suzuki-Miyaura Coupling Enabled byACS catalysis · 2025Article
- Mechanism of Gold-Catalyzed Arylation-Lactonization: A Density Functional Theory Study on the Role of the (MIC^N)AuCl Complex in Au(I)/Au(III) Catalysis.Inorganic chemistry · 2025Article
- Recent Green and Sustainable Pd-Catalyzed Aminations.ChemSusChem · 2025Review
- Room-Temperature Intermolecular Hydroamination of Vinylarenes Catalyzed by Alkali-Metal Ferrate Complexes.ACS organic & inorganic Au · 2025Article
- Mild and Effective Method for the Nickel-Catalyzed Arylation of Glycosyl Thiols in Aqueous Surfactant Solution.The Journal of organic chemistry · 2024Article
- Diversification of Pharmaceutical Manufacturing Processes: Taking the Plunge into the Non-PGM Catalyst Pool.ACS catalysis · 2024Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Substitution of one metal catalyst for another is not as straightforward as simply justifying this change based on the availability and/or cost of the metals. Methodologies to properly assess options for reaction design, including multiple factors like a metal's availability, cost, or environmental indicators have not advanced at the pace needed, leaving decisions to be made along these lines more challenging. Isolated indicators can lead to conclusions being made in too hasty a fashion. Therefore, an extensive life cycle-like assessment was performed documenting that the commonly held view that methods using earth-abundant metals (and in this case study, Ni) are inherently green replacements for methods using palladium in cross-coupling reactions, and Suzuki-Miyaura couplings, in particular, is an incomplete analysis of the entire picture. This notion can be misleading, and unfortunately derives mainly from the standpoint of price, and to some degree, relative natural abundance associated with the impact of mining of each metal. A more accurate picture emerges when several additional reaction parameters involved in the compared couplings are considered. The analysis points to the major impact that use of organic solvents has in these couplings, while the metals themselves actually play subordinate roles in terms of CO
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.