Evidence map›Paper›PMID 38903105›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Associations between mosaic loss of sex chromosomes and incident hospitalization for atrial fibrillation in the United Kingdom.

Jungeun Lim, Aubrey K Hubbard, Batel Blechter, Jianxin Shi, Weiyin Zhou, Erikka Loftfield, Mitchell J Machiela, Jason Y Y Wong

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PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Jungeun LimEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.
Aubrey K HubbardDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Batel BlechterDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jianxin ShiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Weiyin ZhouDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Erikka LoftfieldDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jason Y Y WongEpidemiology and Community Health Branch, National Heart Lung and Blood Institute, Bethesda, MD, USA.ORCID 0000-0003-2820-2133

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Mosaic loss of chromosome Y (mLOY) in leukocytes of men reflects genomic instability from aging, smoking, and environmental exposures. A similar mosaic loss of chromosome X (mLOX) occurs among women. However, the associations between mLOY, mLOX, and risk of incident heart diseases are unclear. Methods: We estimated associations between mLOY, mLOX, and risk of incident heart diseases requiring hospitalization, including atrial fibrillation, myocardial infarction, ischemic heart disease, cardiomyopathy, and heart failure. We analyzed 190,613 men and 224,853 women with genotyping data from the UK Biobank. Among these participants, we analyzed 37,037 men with mLOY and 13,978 women with mLOX detected using Mosaic Chromosomal Alterations caller. Multivariable Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of each incident heart disease in relation to mLOY in men and mLOX in women. Additionally, Mendelian randomization (MR) was conducted to estimate causal associations. Results: Among men, detectable mLOY was associated with elevated risk of atrial fibrillation (HR=1.06, 95%CI:1.03-1.11). The associations were apparent in both never-smokers (HR=1.07, 95%:1.01-1.14) and ever-smokers (HR=1.05, 95%CI:1.01-1.11) as well as men > and ≤60 years of age. MR analyses supported causal associations between mLOY and atrial fibrillation (HR Conclusions: Our findings suggest that mLOY and mLOX reflect sex-specific biological processes or exposure profiles related to incident atrial fibrillation requiring hospitalization.

Indexed as

atrial fibrillationheart diseaseincident relative riskMosaic loss of sex chromosomesprospective cohort study

Identifiers

PMID38903105
PMCPMC11188119

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