Evidence map›Paper›PMID 38903102›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Associations Between Stroke Type, Ischemic Stroke Subtypes, and Post-Stroke Cognitive Trajectories.

Deborah A Levine, Rachael T Whitney, Wen Ye, Emily M Briceño, Alden L Gross, Bruno J Giordani, Jeremy B Sussman, Ronald M Lazar, Virginia J Howard, Hugo J Aparicio and 12 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors.

Deborah A LevineDepartment of Internal Medicine, University of Michigan (U-M), Ann Arbor, MI.ORCID 0000-0002-6864-8001
Rachael T WhitneyDepartment of Internal Medicine, University of Michigan (U-M), Ann Arbor, MI.
Wen YeDepartment of Biostatistics, U-M, Ann Arbor, MI.
Emily M BriceñoDepartment of Physical Medicine and Rehabilitation, U-M, Ann Arbor, MI.ORCID 0000-0002-9360-8917
Alden L GrossDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-4678-0562
Bruno J GiordaniDepartment of Psychiatry, U-M, Ann Arbor, MI.ORCID 0000-0001-5921-3455
Jeremy B SussmanDepartment of Internal Medicine, University of Michigan (U-M), Ann Arbor, MI.ORCID 0000-0002-2158-3618
Ronald M LazarDepartment of Neurology University of Alabama at Birmingham, AL.ORCID 0000-0002-7388-042X
Virginia J HowardDepartment of Epidemiology, University of Alabama at Birmingham, AL.ORCID 0000-0003-4912-9975
Hugo J AparicioDepartment of Neurology, Boston University, MA.ORCID 0000-0001-8584-1455
Alexa S BeiserDepartment of Neurology, Boston University, MA.ORCID 0000-0001-8551-7778
Mitchell S V ElkindDepartment of Neurology, Columbia University, New York, NY.ORCID 0000-0003-2562-1156
Rebecca F GottesmanStroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD.ORCID 0000-0002-9504-1256
Silvia KotonDepartment of Epidemiology, Johns Hopkins University, Baltimore, MD.
Sarah T PendleburyNuffield Department of Clinical Neurosciences, University of Oxford, UK; NIHR Biomedical Research Centre, Departments of Medicine and Geratology, Oxford University Hospitals NHS Foundation Trust, UK.ORCID 0000-0003-3603-8388
Adam S KolliparaDepartment of Internal Medicine, University of Michigan (U-M), Ann Arbor, MI.
Mellanie V SpringerDepartment of Neurology, U-M, Ann Arbor, MI.ORCID 0000-0002-6281-0143
Sudha SeshadriDepartment of Neurology, University of Texas San Antonio, TX.ORCID 0000-0001-6135-2622
Jose R RomeroDepartment of Neurology, Boston University, MA.ORCID 0000-0002-1101-2950
Annette L FitzpatrickDepartment of Epidemiology, University of Washington, Seattle, WA.
William T LongstrethDepartment of Epidemiology, University of Washington, Seattle, WA.
Rodney A HaywardDepartment of Internal Medicine, University of Michigan (U-M), Ann Arbor, MI.

Funding

ARIC Neurocognitive Study (ARIC-NCS) Renewal 2023-2028U01HL096812 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JOSEF CORESH, THOMAS H MOSLEY · 2010 to 2026
$65.7M
ARIC Neurocognitive Study (ARIC-NCS) Renewal 2 of 5U01HL096917 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI MOSLEY, THOMAS H · 2010 to 2018
$11.9M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Stroke, Cognition and Neuroepidemiology SectionZIANS009435 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI GOTTESMAN, REBECCA F · 2022 to 2025
$8.2M
ARIC Neurocognitive Study (ARIC-NCS) Renewal UNC 4 of 5U01HL096899 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI COUPER, DAVID J · 2010 to 2018
$7.5M
ARIC Neurocognitive Study (ARIC-NCS)U01HL096902 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUTSEY, PAMELA L. · 2010 to 2018
$7.4M
The Effect of Vascular Risk Factors on Risk of Alzheimer's Disease and Related Dementias after Stroke (STROKE COG)RF1AG068410 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2020 to 2020
$3.1M
Measurement of cognition and functional decline in Latinx older adults for detection of Alzheimer’s Disease and Related Dementias: A mixed-methods approachK23AG080035 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Emily Marie Briceno · 2023 to 2026
$767k
The Effect of Vascular Risk Factors on Risk of Alzheimer's Disease and Related Dementias after Stroke (STROKE COG)R01AG068410 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LEVINE, DEBORAH ALLISON · 2024 to 2024
$745k
NHLBI NIH HHS U01 HL096812NHLBI NIH HHS U01 HL096899NHLBI NIH HHS U01 HL096902NHLBI NIH HHS U01 HL096917NIA NIH HHS K23 AG080035NIA NIH HHS R01 AG068410NIA NIH HHS RF1 AG068410NIDDK NIH HHS P30 DK092926
6 · The paper itself

Abstract

Background: It is unclear how post-stroke cognitive trajectories differ by stroke type and ischemic stroke subtype. We studied associations between stroke types (ischemic, hemorrhagic), ischemic stroke subtypes (cardioembolic, large artery atherosclerotic, lacunar/small vessel, cryptogenic/other determined etiology), and post-stroke cognitive decline. Methods: This pooled cohort analysis from four US cohort studies (1971-2019) identified 1,143 dementia-free individuals with acute stroke during follow-up: 1,061 (92.8%) ischemic, 82 (7.2%) hemorrhagic, 49.9% female, 30.8% Black. Median age at stroke was 74.1 (IQR, 68.6, 79.3) years. Outcomes were change in global cognition (primary) and changes in executive function and memory (secondary). Outcomes were standardized as T-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1-SD difference in cognition. Median follow-up for the primary outcome was 6.0 (IQR, 3.2, 9.2) years. Linear mixed-effects models estimated changes in cognition after stroke. Results: On average, the initial post-stroke global cognition score was 50.78 points (95% CI, 49.52, 52.03) in ischemic stroke survivors and did not differ in hemorrhagic stroke survivors (difference, -0.17 points [95% CI, -1.64, 1.30]; Conclusion: Stroke survivors had cognitive decline in multiple domains. Declines did not differ by stroke type or ischemic stroke subtype.

Indexed as

Blood PressureCerebrovascular Disease/StrokeCholesterolCognitionCognitive ImpairmentGlucoseHealth ServicesQuality and OutcomesRisk FactorsStroke

Identifiers

PMID38903102
PMCPMC11188123

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.