Evidence map›Paper›PMID 38903089›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Integrating Genetic and Transcriptomic Data to Identify Genes Underlying Obesity Risk Loci.

Hanfei Xu, Shreyash Gupta, Ian Dinsmore, Abbey Kollu, Anne Marie Cawley, Mohammad Y Anwar, Hung-Hsin Chen, Lauren E Petty, Sudha Seshadri, Misa Graff and 18 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Hanfei XuDepartment of Biostatistics, School of Public Health, Boston University, 801 Massachusettes Ave, Boston, MA, 02118, USA.
Shreyash GuptaDepartment of Population Health Sciences, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.
Ian DinsmoreDepartment of Genomic Health, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.
Abbey KolluDepartment of Psychology and Neuroscience, University of North Carolina, 235 E. Cameron Avenue, Chapel Hill, NC, 27599, USA.
Anne Marie CawleyMarsico Lung Institute, University of North Carolina, 125 Mason Farm Rd, Chapel Hill, NC, 27599, USA.
Mohammad Y AnwarDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.
Hung-Hsin ChenInstitute of Biomedical Sciences, Academia Sinica, No. 128, Section 2, Academia Rd., Taipei, Nangang District, 115201, Taiwan.
Lauren E PettyVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, 37232, USA.
Sudha SeshadriDepartment of Biostatistics, School of Public Health, Boston University, 801 Massachusettes Ave, Boston, MA, 02118, USA.
Misa GraffDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-6380-1735
Piper BelowVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical Center, 1161 21st Ave S, Nashville, TN, 37232, USA.
Jennifer A BrodyDepartment of Medicine, Cardiovascular Health Research Unit, University of Washington, 1730 Minor Ave, Seattle, WA, 98101, USA.ORCID 0000-0001-8509-148X
Geetha ChittoorDepartment of Population Health Sciences, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.
Susan P Fisher-HochDepartment of Epidemiology, School of Public Health, UT Health Houston, Regional Academic Health Center, One West University Blvd, Brownsville, TX, 78520, USA.
Nancy L Heard-CostaFramingham Heart Study, 73 Mt Wayte Ave, Framingham, MA, 01702, USA.ORCID 0000-0001-9730-0306
Daniel LevyPopulation Sciences Branch, National Heart, Lung, and Blood Institute of the National Institutes of Health, 6701 Rockledge Drive, Bethesda, MD, 20892, USA.
Honghuang LinDepartment of Medicine, University of Massachusetts Chan Medical School, 55 N Lake Ave, Worcester, MA, 01655, USA.ORCID 0000-0003-3043-3942
Ruth Jf LoosCharles Bronfman Institute for Personalized Medicine at Mount Sinai, Icahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Pl, New York, NY, 10029, USA.
Joseph B MccormickDepartment of Epidemiology, School of Public Health, UT Health Houston, Regional Academic Health Center, One West University Blvd, Brownsville, TX, 78520, USA.ORCID 0000-0002-5844-8102
Jerome I RotterDepartment of Pediatrics, The Institute for Translational Genomics and Population Sciences, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, 1124 West Carson Street, Torrance, CA, 90502, USA.ORCID 0000-0001-7191-1723
Tooraj MirshahiDepartment of Genomic Health, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.
Christopher D StillCenter for Obesity and Metabolic Health, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.
Anita DestefanoDepartment of Biostatistics, School of Public Health, Boston University, 801 Massachusettes Ave, Boston, MA, 02118, USA.
L Adrienne CupplesDepartment of Biostatistics, School of Public Health, Boston University, 801 Massachusettes Ave, Boston, MA, 02118, USA.
Karen L MohlkeDepartment of Genetics, School of Medicine, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0000-0001-6721-153X
Kari E NorthDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 135 Dauer Drive, Chapel Hill, NC, 27599, USA.ORCID 0000-0002-8903-0366
Anne E JusticeDepartment of Population Health Sciences, Geisinger, 100 N. Academy Ave., Danville, PA, 17822, USA.ORCID 0000-0002-8903-8712
Ching-Ti LiuDepartment of Biostatistics, School of Public Health, Boston University, 801 Massachusettes Ave, Boston, MA, 02118, USA.ORCID 0000-0002-0703-0742

Funding

FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Center for Clinical and Translational Sciences (CCTS)UL1TR000371 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MCPHERSON, DAVID D · 2012 to 2016
$13.4M
TU SALUD SI CUENTA: A COMMUNITY BASED MEDIA INTERVENTION FOR MEXICAN AMERICANP20MD000170 · NIMHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI RESTREPO, BALANCA · 2003 to 2012
$13.1M
Polygenic Risk Scores for Diverse Populations - Bridging Research and Clinical CareR01HL151152 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Christy Leigh Avery, Jennifer Below · 2020 to 2026
$12.3M
Leveraging multi-omics approaches to examine metabolic challenges of obesity in relation to cardiovascular diseasesR01HL143885 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI AVERY, CHRISTY LEIGH, GORDON-LARSEN, PENNY · 2019 to 2022
$8.9M
PAGE III: Population Architecture using Genomics and EpidemiologyR01HG010297 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI GIGNOUX, CHRISTOPHER R, MATISE, TARA C. · 2019 to 2022
$6.5M
Gene-Environment Interactions and Weight GainR01HD057194 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GORDON-LARSEN, PENNY, NORTH, KARI E. · 2008 to 2019
$5.9M
Hispanic Latino Lipid ConsortiumR01HL142302 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jennifer Below, JOSEPH MCCORMICK · 2018 to 2026
$5.8M
Integrative Approaches to Identifying Function and Clinical Significance of Adiposity Susceptibility GenesR01DK122503 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Anne Justice, Ching-Ti Liu · 2020 to 2026
$4.5M
Leveraging Hispanic/Latino diversity to map and characterize cardiovascular disease lociR01HL163262 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Lindsay Fernandez-Rhodes, Mariaelisa Graff · 2023 to 2026
$2.9M
Leveraging metabolic pathways and gene expression data to propel understanding of severe obesity in a vulnerable and understudied populationR01DK139598 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Jennifer Below, PENNY GORDON-LARSEN · 2024 to 2026
$2.1M
NCATS NIH HHS UL1 TR000371NHGRI NIH HHS R01 HG010297NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL142302NHLBI NIH HHS R01 HL143885NHLBI NIH HHS R01 HL151152NHLBI NIH HHS R01 HL163262NICHD NIH HHS R01 HD057194NIDDK NIH HHS R01 DK122503NIDDK NIH HHS R01 DK139598NIMHD NIH HHS P20 MD000170
6 · The paper itself

Abstract

Genome-wide association studies (GWAS) have identified numerous body mass index (BMI) loci. However, most underlying mechanisms from risk locus to BMI remain unknown. Leveraging omics data through integrative analyses could provide more comprehensive views of biological pathways on BMI. We analyzed genotype and blood gene expression data in up to 5,619 samples from the Framingham Heart Study (FHS). Using 3,992 single nucleotide polymorphisms (SNPs) at 97 BMI loci and 20,692 transcripts within 1 Mb, we performed separate association analyses of transcript with BMI and SNP with transcript (P

Identifiers

PMID38903089
PMCPMC11188121

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.