Evidence map›Paper›PMID 38903080›Full record

ArticlebioRxiv : the preprint server for biology2024

Generation of hiPSC-derived brain microvascular endothelial cells using a combination of directed differentiation and transcriptional reprogramming strategies.

Aomeng Cui, Ronak Patel, Patrick Bosco, Ugur Akcan, Emily Richters, Paula Barrilero Delgado, Dritan Agalliu, Andrew A Sproul

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Aomeng Cui
Ronak Patel
Patrick Bosco
Ugur Akcan
Emily Richters
Paula Barrilero Delgado
Dritan Agalliu

Funding

Medical Scientist Training ProgramT32GM145440 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STEVEN L REINER · 2022 to 2026
$7.3M
Neuronal Regulation of Vascular Development and Maturation in the RetinaR01EY033994 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Dritan Agalliu · 2022 to 2026
$2.3M
Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB modelR33HL159949 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, LIS, RAPHAEL · 2023 to 2025
$2.2M
Assessing the effects of peripheral immune activation on the NVU following TBI using avascularized and perfused human blood/BBB model.R61HL159949 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, LIS, RAPHAEL · 2021 to 2022
$1.9M
Developing a microfluidic human neurovascular unit system to investigate genetic and age-related risk factors in Alzheimer's diseaseRF1AG078352 · NIA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI AGALLIU, DRITAN, SPROUL, ANDREW ALEXANDER · 2022 to 2024
$1.4M
NEI NIH HHS R01 EY033994NHLBI NIH HHS R33 HL159949NHLBI NIH HHS R61 HL159949NIA NIH HHS RF1 AG078352NIGMS NIH HHS T32 GM145440
6 · The paper itself

Abstract

The blood-brain barrier (BBB), formed by specialized brain microvascular endothelial cells (BMECs), regulates brain function in health and disease.

Identifiers

PMID38903080
PMCPMC11188081

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.