Evidence map›Paper›PMID 38902966›Full record

ArticleThe oncologist2024

Enhanced stiffness in peri-cancerous tissue: a marker of poor prognosis in papillary thyroid carcinoma with lymph node metastasis.

Lei Hu, Lei Ye, Chong Pei, Chunlei Sun, Chaoxue Zhang, Fan Jiang, Nianan He, Weifu Lv

Erratum issuedAbstract read
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In one paragraph

Article in The oncologist, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Lei HuDepartment of Ultrasound, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of People's Republic of China, Hefei, Anhui 230001, People's Republic of China.ORCID 0000-0002-6871-3547
Lei YeDepartment of Ultrasound, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of People's Republic of China, Hefei, Anhui 230001, People's Republic of China.
Chong PeiDepartment of Respiratory and Critical Care Medicine, The First People's Hospital of Hefei City, The Third Affiliated Hospital of Anhui Medical University, Hefei 230001, People's Republic of China.
Chunlei SunDepartment of Thyroid and Breast Surgery, The First Affiliated Hospital of USTC, University of Science and Technology of People's Republic of China, Hefei, 230001, People's Republic of China.
Chaoxue ZhangDepartment of Ultrasound, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, People's Republic of China.
Fan JiangDepartment of Ultrasound, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230001, People's Republic of China.
Nianan HeDepartment of Ultrasound, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of People's Republic of China, Hefei, Anhui 230001, People's Republic of China.
Weifu LvDepartment of Radiology, The First Affiliated Hospital of USTC, University of Science and Technology of People's Republic of China, Hefei 230001, People's Republic of China.

Funding

Joint Fund for Medical Artificial Intelligence MAI2023Q020Joint Fund Project for "USTC New Medicine" YD9110002030
6 · The paper itself

Abstract

backgroundThe prognostic significance of lymph node metastasis (LNM) in papillary thyroid carcinoma (PTC) remains controversial. Notably, there is evidence suggesting an association between tissue stiffness and the aggressiveness of the disease. We therefore aimed to explore the effect of tissue stiffness on LNM-related invasiveness in PTC patients.

methodA total of 2492 PTC patients from 3 hospitals were divided into an LNM group and a non-LNM group based on their pathological results. The effects of interior lesion stiffness (E) and peri-cancerous tissue stiffness (Eshell) on the LNM-related recurrence rate and mortality in each patient with PTC subgroup were analyzed. The activation of cancer-associated fibroblasts (CAFs) and extracellular matrix component type 1 collagen (COL-I) in the lesion were compared and analyzed across different subgroups. The underlying biological basis of differences in each subgroup was identified using RNA sequencing (RNA-seq) data.

resultsThe Eshell value and Eshell/E in the LNM group were significantly higher than those in the non-LNM group of patients with PTC (Eshell: 72.72 ± 5.63 vs 66.05 ± 4.46; Eshell/E: 1.20 ± 1.72 vs 1.09 ± 1.10, P < .001). When Eshell/E > 1.412 and LNM were both present, the recurrence rate and mortality were significantly increased compared to those of group of patients with LNM (91.67% and 7.29%, respectively). The CAF activation and COL-I content in the Eshell/E+ group were significantly higher than those in the Eshell/E- group (all P < .001), and the RNA-seq results revealed significant extracellular matrix (ECM) remodeling in the LNM-Eshell/E+ group.

conclusionsStiff peri-cancerous tissue induced CAF activation, COL-I deposition, and ECM remodeling, resulting in a poor prognosis for PTC patients with LNM.

Indexed as

Lymphatic MetastasisThyroid Cancer, PapillaryThyroid NeoplasmsAdultFemaleHumansMaleMiddle AgedPrognosiscancer-associated fibroblastslymph node metastasisperi-cancerous tissuestiffnessthyroid cancer

Identifiers

PMID38902966
PMCPMC11379648

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.