Evidence map›Paper›PMID 38902929›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2024

Piperacillin/Tazobactam Susceptibility Test Interpretive Criteria for Enterobacterales: Recommendations From the United States Committee on Antimicrobial Susceptibility Testing.

Thomas P Lodise, Sujata M Bhavnani, Paul G Ambrose, Helio S Sader, David Andes, Jason M Pogue

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guideline for antimicrobial treatment of multidrug-resistant Gram-negative infections: practice recommendations of the Brazilian Society of Infectious Diseases.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Guideline
  2. Article
  3. Whole-Genome Sequencing Analysis of Drug-ResistantPathogens (Basel, Switzerland) · 2025
    Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Thomas P LodiseDepartment of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA.ORCID 0000-0002-4730-0655
Sujata M BhavnaniInstitute for Clinical Pharmacodynamics, Inc, Schenectady, New York, USA.
Paul G AmbroseInstitute for Clinical Pharmacodynamics, Inc, Schenectady, New York, USA.
Helio S SaderJMI Laboratories, North Liberty, Iowa, USA.
David AndesDepartment of Medicine, Department of Medical Microbiology and Immunology, School of Medicine and Public Health and School of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jason M PogueDepartment of Clinical Pharmacy, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The in vitro susceptibility testing interpretive criteria (STIC) for piperacillin/tazobactam (TZP) against Enterobacterales were recently updated by the US Food and Drug Administration, Clinical and Laboratory Standards Institute, and European Committee on Antimicrobial Susceptibility Testing. The United States Committee on Antimicrobial Susceptibility Testing (USCAST) also recently reviewed TZP STIC for Enterobacterales and arrived at different STIC for Enterobacterales. Here, we explain our recommendations and rationale behind them. Based on our review of the available data, USCAST does not recommend TZP STIC for certain Enterobacterales species that have a moderate to high likelihood of clinically significant AmpC production (Enterobacter cloacae, Citrobacter freundii, and Klebsiella aerogenes only) or for third-generation cephalosporin-nonsusceptible Enterobacterales. USCAST recommends a TZP susceptibility breakpoint of ≤ 16/4 mg/L for third-generation cephalosporin-susceptible Enterobacterales and only endorses the use of extended infusion TZP regimens for patients with infections due to these pathogens.

Indexed as

Anti-Bacterial AgentsEnterobacteriaceaeMicrobial Sensitivity TestsPiperacillin, Tazobactam Drug CombinationEnterobacteriaceae InfectionsHumansUnited StatesAnti-Bacterial AgentsPiperacillin, Tazobactam Drug CombinationAmpCEnterobacteralesESBLpiperacillin/tazobactamsusceptibility

Identifiers

PMID38902929
PMCPMC11650869

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.