Evidence map›Paper›PMID 38902833›Full record

ArticleStem cell research & therapy2024

Improvement of multilineage hematopoiesis in hematopoietic stem cell-transferred c-kit mutant NOG-EXL humanized mice.

Ryoji Ito, Yusuke Ohno, Yunmei Mu, Yuyo Ka, Shuko Ito, Maiko Emi-Sugie, Misa Mochizuki, Kenji Kawai, Motohito Goto, Tomoyuki Ogura and 4 more

Abstract read
In one paragraph

Article in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Humanized mouse models in MDS.Cell death & disease · 2025
    Review
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryoji ItoCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan. rito@ciea.or.jp.ORCID 0000-0003-2903-2332
Yusuke OhnoCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Yunmei MuCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Yuyo KaCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Shuko ItoCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Maiko Emi-SugieCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Misa MochizukiCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Kenji KawaiCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Motohito GotoCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Tomoyuki OguraCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Riichi TakahashiCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Akira NiwaDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, 606-8507, Japan.
Tatsutoshi NakahataCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.
Mamoru ItoCentral Institute for Experimental Medicine and Life Science, Kawasaki, Kanagawa, 210-0821, Japan.

Funding

Japan Society for the Promotion of Science 18H03975Japan Society for the Promotion of Science #25430099
6 · The paper itself

Abstract

Human hematopoietic stem cell (HSC)-transferred humanized mice are valuable models for exploring human hematology and immunology. However, sufficient recapitulation of human hematopoiesis in mice requires large quantities of enriched human CD34

Indexed as

HematopoiesisHematopoietic Stem CellsHematopoietic Stem Cell TransplantationProto-Oncogene Proteins c-kitAnimalsAntigens, CD34Cell LineageHumansInterleukin-3MiceMice, TransgenicMutationAntigens, CD34Interleukin-3Proto-Oncogene Proteins c-kitCD34+ cellsHematopoiesisHematopoietic stem cellsHumanized miceNOG

Identifiers

PMID38902833
PMCPMC11191313

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.