Evidence map›Paper›PMID 38902784›Full record

ArticleBMC research notes2024

Leptospira spp. and Rickettsia spp. as pathogens with zoonotic potential causing acute undifferentiated febrile illness in a central-eastern region of Peru.

Wilmer Silva-Caso, Miguel Angel Aguilar-Luis, Walter Espinoza-Espíritu, Mercedes Vilcapoma-Balbin, Luis J Del Valle, Erika Misaico-Revate, Fernando Soto-Febres, Giancarlo Pérez-Lazo, Johanna Martins-Luna, Francisco Perona-Fajardo and 1 more

Abstract read
In one paragraph

Article in BMC research notes, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Detection of zoonotic pathogens in invasive black rats (Frontiers in veterinary science · 2026
    Article
  3. Article
  4. High Burden of Coinfections With Epidemic-Prone Pathogens Among Febrile Patients in Nigeria: A Multi-Pathogen Surveillance Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wilmer Silva-CasoSchool of Medicine, Research Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. wilmer.silva@upc.pe.
Miguel Angel Aguilar-LuisSchool of Medicine, Research Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Walter Espinoza-EspírituRed de Salud Leoncio Prado. Ministerio de Salud, Huánuco, Peru.
Mercedes Vilcapoma-BalbinRed de Salud Leoncio Prado. Ministerio de Salud, Huánuco, Peru.
Luis J Del ValleCentre d'Enginyeria Biotecnologica i Molecular (CEBIM), Departament d'Enginyeria Quıímica, ETSEIB, Universidad Politécnica de Catalunya (UPC), Barcelona Tech, Spain.
Erika Misaico-RevateHospital de Tingo María, Ministerio de Salud del Peru, Huánuco, Peru.
Fernando Soto-FebresDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima, 15033, Peru.
Giancarlo Pérez-LazoDivision of Infectious Diseases, Guillermo Almenara Irigoyen National Hospital-EsSalud, Lima, 15033, Peru.
Johanna Martins-LunaSchool of Medicine, Research Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Francisco Perona-FajardoSchool of Medicine, Research Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
Juana Del Valle-MendozaSchool of Medicine, Research Centre of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. juana.delvalle@upc.pe.

Funding

Universidad Peruana de Ciencias Aplicadas EXP007-2016
6 · The paper itself

Abstract

objetivethis study was to determine the relationship between acute febrile illness and bacterial pathogens with zoonotic potential that cause emerging and re-emerging diseases in a central-eastern region of Peru.

resultsOut of the 279 samples analyzed, 23 (8.2%) tested positive for infection by Rickettsia spp., while a total of 15 (5.4%) tested positive for Leptospira spp. Women had a higher frequency of infection by Rickettsia spp., with 13 cases (53.3%), while men had a higher frequency of infection by Leptospira spp., with 10 cases (66.7%). The most frequently reported general symptom was headache, with 100.0% (n = 23) of patients with Rickettsia (+) and 86.7% (n = 13) of patients with Leptospira (+) experiencing it. Arthralgia was the second most frequent symptom, reported by 95.6% (n = 22) and 60% (n = 9) of patients with Rickettsia (+) and Leptospira (+), respectively. Myalgia was reported by 91.3% (n = 21) and 66.7% (n = 10) of patients with Rickettsia (+) and Leptospira (+), respectively. Retroocular pain, low back pain, and skin rash were also present, but less frequently. Among the positives, no manifestation of bleeding was recorded, although only one positive case for Leptospira spp. presented a decrease in the number of platelets.

Indexed as

LeptospiraLeptospirosisRickettsiaRickettsia InfectionsAdolescentAdultAnimalsArthralgiaFemaleFeverHeadacheHumansMaleMiddle AgedMyalgiaPeruFeverLeptospiraRickettsia

Identifiers

PMID38902784
PMCPMC11188165

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.