Evidence map›Paper›PMID 38902753›Full record

ReviewJournal of cardiothoracic surgery2024

Pathological findings of pulmonary papillary adenoma with EGFR mutation and literature review: two cases report.

Lu Huang, Yi Liu, Changjun Yi, Lin Han, Shuang Li, Xingzi Li, Xuehui Wu

Abstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of cardiothoracic surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lu HuangDepartment of Pathology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443000, China.
Yi LiuDepartment of Pathology, Yiling Hospital, Yichang, 443100, China.
Changjun YiYichang Ackerman Pathological Diagnostic Centre, Yichang, 443000, China.
Lin HanDepartment of Pathology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443000, China.
Shuang LiDepartment of Pathology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443000, China.
Xingzi LiDepartment of Pathology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443000, China.
Xuehui WuDepartment of Pathology, The First College of Clinical Medical Science, China Three Gorges University, Yichang, 443000, China. 76043575@qq.com.

Funding

Third Level Laboratory of Traditional Chinese Medicine Pharmacology Research of the State Administration of Traditional Chinese Medicine 2023PTCM14
6 · The paper itself

Abstract

objectivePulmonary papillary adenoma is an extremely rare benign tumor. It is derived from type II lung cells and club cells, suggesting that it may originate from stem cells with two-way differentiation. Only one case has been reported with FGFR2-IIIb overexpression.

methodsTwo cases of pulmonary papillary adenoma with available data on clinical features, histological morphology, immunophenotype and molecular characteristics were analyzed.

resultsBoth tumors were well-circumscribed unencapsulated nodules composed of papillary structures with fibrovascular cores lined by a single layer of cuboidal or columnar epithelium without necrosis, nuclear atypia and mitoses, or invasion. But malignant transformation features include complex branching structures and significantly enlarged, irregular, and crowded malignant cells in one case. Immunohistochemistry showed that the tumor cells were strongly positive for TTF1, NapsinA, EMA and CK7 and negative for CEA and P63, with a low Ki-67 proliferation index. The EGFR somatic mutation exon19:c.2236_2256delinsATC (p.E746_S752delinsI) was found in one case by next-generation sequencing (NGS) technology.

conclusionPulmonary papillary adenoma is very rare. Virtually all papillary adenomas are clinically silent and discovered incidentally. They are benign tumors, and resection is curative. An EGFR 19 exon deletion mutation in a patient with this tumor type was detected for the first time by NGS, and our results suggest that the malignant transformation of pulmonary papillary adenoma may be mediated by EGFR mutation.

Indexed as

AdenomaErbB ReceptorsLung NeoplasmsMutationHumansImmunohistochemistryEGFR protein, humanErbB ReceptorsClinicopathological featuresEGFR mutationLungPapillary adenoma

Identifiers

PMID38902753
PMCPMC11188281

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.