Evidence map›Paper›PMID 38902587›Full record

ArticleAnnals of nuclear medicine2024

Differential centiloid scale normalization techniques: comparison between hybrid PET/MRI and independently acquired MRI.

Ryo Yamakuni, Takenobu Murakami, Naoyuki Ukon, Takeyasu Kakamu, Wataru Toda, Kasumi Hattori, Hirofumi Sekino, Shiro Ishii, Kenji Fukushima, Hiroshi Matsuda and 4 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Annals of nuclear medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Sequential scans ofJapanese journal of radiology · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryo YamakuniDepartment of Radiology and Nuclear Medicine, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan. yamakuni@fmu.ac.jp.ORCID http://orcid.org/0000-0003-0265-5636
Takenobu MurakamiDivision of Neurology, Department of Brain and Neurosciences, Faculty of Medicine, Tottori University, Tottori, Japan.
Naoyuki UkonAdvanced Clinical Research Center, Fukushima Medical University, Fukushima, Japan.
Takeyasu KakamuDepartment of Hygiene and Preventive Medicine, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Wataru TodaDepartment of Neuropsychiatry, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Kasumi HattoriDepartment of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Hirofumi SekinoDepartment of Radiology and Nuclear Medicine, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Shiro IshiiDepartment of Radiology and Nuclear Medicine, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Kenji FukushimaDepartment of Radiology and Nuclear Medicine, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.
Hiroshi MatsudaDepartment of Bio-Functional Imaging, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Yoshikazu UgawaDepartment of Human Neurophysiology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
Noritaka WakasugiIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Mitsunari AbeIntegrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hiroshi ItoDepartment of Radiology and Nuclear Medicine, School of Medicine, Fukushima Medical University, 1 Hikariga-oka, Fukushima, 960-1295, Japan.

Funding

the Japan Agency for Medical Research and Development (AMED, www.amed.go.jp) 18dm0307003h0001
6 · The paper itself

Abstract

objectiveCentiloid (CL) scales play an important role in semiquantitative analyses of amyloid-β (Aβ) PET. CLs are derived from the standardized uptake value ratio (SUVR), which needs Aβ positron emission tomography (PET) normalization processing. There are two methods to collect the T1-weighted imaging (T1WI) for normalization: (i) anatomical standardization using simultaneously acquired T1WI (PET/MRI), usually adapted to PET images from PET/MRI scanners, and (ii) T1WI from a separate examination (PET + MRI), usually adapted to PET images from PET/CT scanners. This study aimed to elucidate the correlations and differences in CLs between when using the above two T1WI collection methods.

methodsAmong patients who underwent Aβ PET/MRI (using

resultsBetween PET/MRI and PET + MRI methods, CLs correlated linearly in

conclusionsAnatomical standardizations using PET/MRI and using PET + MRI can lead to almost equivalent CL. The CL values obtained using PET/MRI or PET + MRI normalization methods are consistent and comparable in clinical studies.

Indexed as

Image Processing, Computer-AssistedMagnetic Resonance ImagingMultimodal ImagingPositron-Emission TomographyAgedAged, 80 and overAlzheimer DiseaseAmyloid beta-PeptidesBrainFemaleHumansMaleMiddle AgedAmyloid beta-PeptidesAlzheimer diseaseAmyloidCentiloid scaleNormalizationPET/MRIPositron emission tomography

Identifiers

PMID38902587

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.