Evidence map›Paper›PMID 38902519›Full record

ArticleNature immunology2024

Vaccination reduces central nervous system IL-1β and memory deficits after COVID-19 in mice.

Abigail Vanderheiden, Jeremy D Hill, Xiaoping Jiang, Ben Deppen, Gayan Bamunuarachchi, Nadia Soudani, Astha Joshi, Matthew D Cain, Adrianus C M Boon, Robyn S Klein

Abstract read
In one paragraph

Article in Nature immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The neuroimmune system and cognition.Nature immunology · 2026
    Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Combination antiviral and anti-inflammatory therapy mitigates persistent neurological deficits in mice post SARS-CoV-2 infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Neuroimmune pathophysiology of long COVID.Psychiatry and clinical neurosciences · 2025
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Abigail VanderheidenCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0003-1321-4510
Jeremy D HillCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Xiaoping JiangCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Ben DeppenCenter for Neuroimmunology and Neuroinfectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
Gayan BamunuarachchiDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Nadia SoudaniDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Astha JoshiDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Matthew D CainDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Adrianus C M BoonDepartment of Medicine, Washington University School of Medicine, St. Louis, MO, USA.ORCID http://orcid.org/0000-0002-4700-8224
Robyn S KleinSchulich School of Medicine and Dentistry, Department of Microbiology and Immunology, Western University, London, Ontario, Canada. rklein@wustl.edu.ORCID http://orcid.org/0000-0003-0281-1352

Funding

Research Program Award (R35 Clinical Trial Optional) - Dr. Robyn Klein NINDSR35NS122310 · NINDS · WASHINGTON UNIVERSITY · PI CAIN, MATTHEW D · 2021 to 2024
$3.7M
IDENTIFICATION AND CHARACTERIZATION OF RNA STRUCTURES IN THE GENOME OF INFLUENZA VIRUSR01AI139251 · NIAID · WASHINGTON UNIVERSITY · PI BOON, ADRIANUS CM · 2018 to 2021
$2.0M
NEUROPATHOGENESIS OF ZIKA VIRUS INFECTIONSR01NS104471 · NINDS · WASHINGTON UNIVERSITY · PI KLEIN, ROBYN S. · 2018 to 2020
$1.4M
Cytokine-mediated neurologic disease in COVID-19F32NS128065 · NINDS · WASHINGTON UNIVERSITY · PI VANDERHEIDEN, ABIGAIL ROSE · 2022 to 2023
$142k
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) F32NS128065NINDS NIH HHS F32 NS128065NINDS NIH HHS R35 NS122310U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AI139251U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS104471U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R35NS122310
6 · The paper itself

Abstract

Up to 25% of individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibit postacute cognitive sequelae. Although millions of cases of coronavirus disease 2019 (COVID-19)-mediated memory dysfunction are accumulating worldwide, the underlying mechanisms and how vaccination lowers risk are unknown. Interleukin-1 (IL-1), a key component of innate immune defense against SARS-CoV-2 infection, is elevated in the hippocampi of individuals with COVID-19. Here we show that intranasal infection of C57BL/6J mice with SARS-CoV-2 Beta variant leads to central nervous system infiltration of Ly6C

Indexed as

COVID-19HippocampusInterleukin-1betaMemory DisordersMice, Inbred C57BLNeurogenesisSARS-CoV-2AnimalsCOVID-19 VaccinesDisease Models, AnimalFemaleHumansMaleMiceMicrogliaMonocytesCOVID-19 VaccinesIL1B protein, mouseInterleukin-1betaReceptors, Interleukin-1 Type ISpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2

Identifiers

PMID38902519
PMCPMC13148132

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.