Evidence map›Paper›PMID 38902516›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2024

Time to positivity of blood cultures in a level IV NICU varies based on organism category and population subgroups: is a 36-hour rule out safe?

Yo Nishihara, Christine E MacBrayne, Andrea Prinzi, Kelly Pearce, Diane Melara, Blair W Weikel, Jeanne Zenge, Theresa Grover, Sarah K Parker

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Yo NishiharaDepartment of Neonatology, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA. yo.nishihara@childrenscolorado.org.ORCID 0009-0001-8110-7269
Christine E MacBrayneDepartment of Pharmacy, Children's Hospital Colorado, Aurora, CO, USA.
Andrea PrinziGraduate School of Medicine, University of Colorado, Aurora, CO, USA.
Kelly PearceDepartment of Epidemiology, Children's Hospital Colorado, Aurora, CO, USA.
Diane MelaraDepartment of Neonatology, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA.
Blair W WeikelDepartment of Neonatology, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA.
Jeanne ZengeDepartment of Neonatology, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA.
Theresa GroverDepartment of Neonatology, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA.
Sarah K ParkerDepartment of Pediatric Infectious Diseases, Children's Hospital Colorado and School of Medicine, University of Colorado, Aurora, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTime to positivity (TTP) of blood cultures and organism characteristics may be different in a Level IV NICU population.

methodsRetrospective study of 309 Level IV NICU positive blood cultures between January 2012 to December 2018 describing TTP and organism characteristics.

resultsMedian TTP [IQR] was 21.1 [14.3, 25.2] hours, with 91.2% positive at 36 h, and 96.1% positive at 48 h. Gram negative definite pathogens had the shortest TTP (13.0 [11.4, 15.4] hours) compared to gram positive definite pathogens (16.3 [13.0, 22.4] hours). TTP for treated gram positive commensal organisms (22.3 [20.1, 30.4] hours) and those considered contaminants (23.6 [21.4, 26.0] hours), was significantly longer than both gram positive and negative definite pathogens.

conclusionWhen antimicrobials are initiated due to concern for bacteremia and blood cultures have not identified a causative pathogen at 36 h, antimicrobials may be safely discontinued in the majority of Level IV NICU patients.

Indexed as

BacteremiaBlood CultureIntensive Care Units, NeonatalAnti-Bacterial AgentsFemaleHumansInfant, NewbornMaleRetrospective StudiesTime FactorsAnti-Bacterial Agents

Identifiers

PMID38902516

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