Evidence map›Paper›PMID 38902460›Full record

ArticleDigestive diseases and sciences2024

Inflammatory Bowel Disease-Associated Arthritis Is Associated with Concomitant Autoimmune and Inflammatory Disorders.

Madeline Alizadeh, Uni Wong, Bernadette C Siaton, Seema A Patil, Lauren George, Jean-Pierre Raufman, William H Scott, Erik C von Rosenvinge, Jacques Ravel, Raymond K Cross

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Madeline AlizadehInstitute for Genome Sciences, University of Maryland School of Medicine, HSF III, 670 W Baltimore St, Baltimore, MD, 21201, USA. madeline.alizadeh@som.umaryland.edu.
Uni WongDepartment of Veterans Affairs, Washington DC Veterans Health Administration, Washington, DC, USA.
Bernadette C SiatonDepartment of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
Seema A PatilDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD, 21201, USA.
Lauren GeorgeDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD, 21201, USA.
Jean-Pierre RaufmanDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD, 21201, USA.
William H ScottDepartment of Veterans Affairs, Veterans Affairs Maryland Health Care System, Baltimore, MD, USA.
Erik C von RosenvingeDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD, 21201, USA.
Jacques RavelInstitute for Genome Sciences, University of Maryland School of Medicine, HSF III, 670 W Baltimore St, Baltimore, MD, 21201, USA.
Raymond K CrossDivision of Gastroenterology and Hepatology, Department of Medicine, University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD, 21201, USA.

Funding

Research Training in Gastroenterology and HepatologyT32DK067872 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI RAUFMAN, JEAN-PIERRE · 2005 to 2024
$7.2M
BLRD VA I01 BX004890NIDDK NIH HHS T32 DK067872NIDDK NIH HHS T32 DK067872-19
6 · The paper itself

Abstract

backgroundExtraintestinal Manifestations (EIMs) are a common and potentially debilitating complication of Inflammatory Bowel Diseases (IBD), sometimes requiring additional treatment beyond those used to control intestinal disease. IBD-associated arthritis (IAA), a form of spondyloarthritis, is associated with several factors including disease location, sex, and IBD type. However, much remains unknown about other clinical factors predicting development of EIMs. Our goal was to identify additional factors associated with IAA.

methodsParticipants in the LOCATION-IBD cohort were included in this analysis. We performed univariate and multivariate analysis of demographics, clinical data, and patient-reported outcomes data.

resultsThe LOCATION-IBD cohort included 182 participants with (n = 53) and without (n = 110) joint EIMs and with joint pain of unclear etiology (n = 19). In a multivariate analysis comparing those with and without joint EIMs, female sex (OR = 2.5, p = 0.014), the presence of concomitant autoimmune and inflammatory disorders (OR = 2.5, p = 0.038), and Crohn's disease (OR = 2.9, p = 0.026) were associated with the presence of joint EIMs.

conclusionThis analysis reveals patients with IAA are more likely to have concomitant autoimmune disorders. Further studies are needed to confirm this association, understand the mechanisms underlying the common pathogenesis of these concurrent disorders, and evaluate their impact on the treatment of IAA.

Indexed as

Inflammatory Bowel DiseasesAdultArthritisAutoimmune DiseasesCrohn DiseaseFemaleHumansMaleMiddle AgedMultivariate AnalysisRisk FactorsSex FactorsAutoimmuneCrohn’s diseaseExtra-intestinal manifestationsIBD-associated spondyloarthritisSpondyloarthritisUlcerative colitis

Identifiers

PMID38902460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.