Evidence map›Paper›PMID 38902404›Full record

SynthesisSurgical endoscopy2024

Smoking status predicts anastomotic leak after esophagectomy: a systematic review & meta-analysis.

Alexandre Bédard, Rahim H Valji, Uzair Jogiat, Kevin Verhoeff, Simon R Turner, Shahzeer Karmali, Janice Y Kung, Eric L R Bédard

Abstract readSystematic ReviewMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Surgical endoscopy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexandre BédardDepartment of Surgery, University of Alberta, Edmonton, Canada.
Rahim H ValjiDepartment of Surgery, University of Alberta, Edmonton, Canada.
Uzair JogiatDepartment of Surgery, University of Alberta, Edmonton, Canada.ORCID 0000-0001-5271-9381
Kevin VerhoeffDepartment of Surgery, University of Alberta, Edmonton, Canada.
Simon R TurnerDepartment of Surgery, University of Alberta, Edmonton, Canada.
Shahzeer KarmaliDepartment of Surgery, University of Alberta, Edmonton, Canada.
Janice Y KungGeoffrey & Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, Canada.
Eric L R BédardDepartment of Surgery, University of Alberta, Edmonton, Canada. ebedard@ualberta.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnastomotic leak after esophagectomy is a major contributor to surgery-related morbidity and mortality. The purpose of this systematic review was to evaluate if positive-smoking status is associated with the incidence of this complication.

methodsA systematic search of MEDLINE, EMBASE, Scopus, Web of Science and Cochrane Library was performed on April 4th, 2023. Inclusion criteria comprised human participants undergoing esophagectomy, age ≥ 18, n ≥ 5, and identification of smoking status. The primary outcome was incidence of anastomotic leak. Sub-group analysis by ex- or current smoking status was performed. Meta-analysis was performed with RevMan 5.4.1 using a Mantel-Haenszel random-effects model. Publication bias was evaluated visually with funnel plots and through the Egger test.

resultsA total of 220 abstracts were screened, of which 69 full-text studies were assessed for eligibility, with 13 studies selected for final inclusion. This included 16,103 patients, of which 4433 were ex- or current smokers, and 9141 were never smokers. Meta-analysis revealed an increased odds of anastomotic leak in patients with a positive-smoking status (current or ex-smokers) compared to never smokers (OR 1.44, 95% CI 1.18-1.76, I

conclusionThe findings of this systematic review and meta-analysis support the association between positive-smoking status and the risk of anastomotic leak after esophagectomy. Results further emphasize the importance of preoperative smoking cessation to reduce post-operative morbidity.

Indexed as

Anastomotic LeakEsophagectomySmokingEsophageal NeoplasmsHumansIncidenceRisk FactorsEsophageal cancerEsophagectomySmoking

Identifiers

PMID38902404

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.