Evidence map›Paper›PMID 38902386›Full record

ArticleInternational journal of obesity (2005)2024

PPARα suppresses low-intensity-noise-induced body weight gain in mice: the activated HPA axis plays an critical role.

Zheng Yan, Jia Luo, Ying Wang, Jie Yang, Mingli Su, Lei Jiang, Julin Yang, Manyun Dai, Aiming Liu

Abstract read
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In one paragraph

Article in International journal of obesity (2005), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zheng Yan *Health Science Center, Ningbo University, Ningbo, 315211, China.ORCID 0000-0002-4698-7686
Jia Luo *Health Science Center, Ningbo University, Ningbo, 315211, China.
Ying WangHealth Science Center, Ningbo University, Ningbo, 315211, China.
Jie YangHealth Science Center, Ningbo University, Ningbo, 315211, China.
Mingli SuHealth Science Center, Ningbo University, Ningbo, 315211, China.ORCID 0000-0002-4522-9242
Lei JiangHealth Science Center, Ningbo University, Ningbo, 315211, China.
Julin YangDepartment of Basic Nutrition, Ningbo College of Health Sciences, Ningbo, 315211, China.
Manyun DaiHealth Science Center, Ningbo University, Ningbo, 315211, China. daimanyun@nbu.edu.cn.ORCID 0000-0002-7184-5129
Aiming LiuHealth Science Center, Ningbo University, Ningbo, 315211, China. liuaiming@nbu.edu.cn.ORCID 0000-0002-5937-6278

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAs the second most risky environmental pollution, noise imposes threats to human health. Exposure to high-intensity noise causes hearing impairment, psychotic disorders, endocrine modifications. The relationship among low-intensity noise, obesity and lipid-regulating nuclear factor PPARα is not yet clear.

methodsIn this study, male wild-type (WT) and Pparα-null (KO) mice on a high-fat diet (HFD) were exposed to 75 dB noise for 12 weeks to explore the effect of low-intensity noise on obesity development and the role of PPARα. 3T3-L1 cells were treated with dexamethasone (DEX) and sodium oleate (OA) to verify the down-stream effect of hypothalamic-pituitary-adrenal (HPA) axis activation on the adipose tissues.

resultsThe average body weight gain (BWG) of WT mice on HFD exposed to noise was inhibited, which was not observed in KO mice. The mass and adipocyte size of adipose tissues accounted for the above difference of BWG tendency. In WT mice on HFD, the adrenocorticotropic hormone level was increased by the noise challenge. The aggravation of fatty liver by noise exposure occurred in both mouse lines, and the transport of hepatic redundant lipid to adipose tissues were similar. The lipid metabolism in adipose tissue driven by HPA axis accorded with the BWG inhibition in vivo, validated in 3T3-L1 adipogenic stem cells.

conclusionChronic exposure to low-intensity noise aggravated fatty liver in both WT and KO mice. BWG inhibition was observed only in WT mice, which covered up the aggravation of fatty liver by noise exposure. PPARα mediates the activation of HPA axis by noise exposure in mice on HFD. Elevated adrenocorticotropic hormone (ACTH) promoted lipid metabolism in adipocytes, which contributed to the disassociation of BWG and fatty liver development in male WT mice. Summary of PPARα suppresses noise-induced body weight gain in mice on high-fat-diet. Chronic exposure to low-intensity noise exposure inhibited BWG by PPARα-dependent activation of the HPA axis.

Indexed as

Hypothalamo-Hypophyseal SystemNoiseObesityPituitary-Adrenal SystemPPAR alphaWeight Gain3T3-L1 CellsAnimalsDiet, High-FatDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, KnockoutPPAR alpha

Identifiers

PMID38902386

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.