Evidence map›Paper›PMID 38902373›Full record

ArticleScientific reports2024

Global ischemia induces stemness and dedifferentiation in human adult cardiomyocytes after cardiac arrest.

Helen Jinton, Victoria Rotter Sopasakis, Linnéa Sjölin, Anders Oldfors, Anders Jeppsson, Jonatan Oras, Mathias Wernbom, Kristina Vukusic

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In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Helen JintonDepartment of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Victoria Rotter SopasakisDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Linnéa SjölinDepartment of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Anders OldforsDepartment of Clinical Chemistry, Sahlgrenska University Hospital, Gothenburg, Sweden.
Anders JeppssonDepartment of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.
Jonatan OrasDepartment of Anaesthesiology and Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden.
Mathias WernbomDepartment of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Kristina VukusicDepartment of Laboratory Medicine, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. kristina.vukusic@gu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Global ischemia has been shown to induce cardiac regenerative response in animal models. One of the suggested mechanisms behind cardiac regeneration is dedifferentiation of cardiomyocytes. How human adult cardiomyocytes respond to global ischemia is not fully known. In this study, biopsies from the left ventricle (LV) and the atrioventricular junction (AVj), a potential stem cell niche, were collected from multi-organ donors with cardiac arrest (N = 15) or without cardiac arrest (N = 6). Using immunohistochemistry, we investigated the expression of biomarkers associated with stem cells during cardiomyogenesis; MDR1, SSEA4, NKX2.5, and WT1, proliferation markers PCNA and Ki67, and hypoxia responsive factor HIF1α. The myocyte nuclei marker PCM1 and cardiac Troponin T were also included. We found expression of cardiac stem cell markers in a subpopulation of LV cardiomyocytes in the cardiac arrest group. The same cells showed a low expression of Troponin T indicating remodeling of cardiomyocytes. No such expression was found in cardiomyocytes from the control group. Stem cell biomarker expression in AVj was more pronounced in the cardiac arrest group. Furthermore, co-expression of PCNA and Ki67 with PCM1 was only found in the cardiac arrest group in the AVj. Our results indicate that a subpopulation of human cardiomyocytes in the LV undergo partial dedifferentiation upon global ischemia and may be involved in the cardiac regenerative response together with immature cardiomyocytes in the AVj.

Indexed as

Cell DedifferentiationHeart ArrestMyocytes, CardiacAdultAgedBiomarkersFemaleHeart VentriclesHumansMaleMiddle AgedStem CellsTroponin TBiomarkersTroponin TAtrioventricular junctionCardiac arrestCardiomyocyte proliferationDedifferentiationHeartHypoxiaRegenerationStem cells

Identifiers

PMID38902373
PMCPMC11190235

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.